Studies on Synthesis and Biological Activities of N-Silylmethyl-N-formyl Aniline Derivatives

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (6): 900.

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Studies on Synthesis and Biological Activities of N-Silylmethyl-N-formyl Aniline Derivatives

ZHANG Zeng-You¹, SHANG Jian², ZHOU Xiu-Zhong²

1. Inst.of Elemento-Org.Chem.of Nankai Univ., Tianjin, 300071;
2. Chem.Dept.of Nankai Univ.

Received:1994-06-29 Revised:1995-02-12 Online:1995-06-24 Published:1995-06-24

Abstract

Abstract: In the presence of the reaction of chloromethylsilanes with substituted anilines in DMF was studied. By means of elementary analysis,IR and ¹HNMR,the products of these reaction are confirmed to be N-silylmethyl-N-formyl aniline derivatives.Twenty-three new compounds(with the general formula:RR'R″SiCH₂N·where R=CH₃;R'=CH₃,p-ClC₆H₄;R″=p-ClC₆H₄,p-FC₆H₄,C₆H₅;Xand Yare H,CH₃,Cl,Frespectively.)have been synthesized.The biological activities of some compounds have been tested,a few of them have good germicidal activities.thus p-FC₆H₄Si(Me₂)CH₂N(CHO)C₆H₄Cl-p at 0.005% gave 100% control of Asparagus stem blight.

Key words: Chloromethylsilane, Dimethylformamide, Benzenamine, Condensation

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ZHANG Zeng-You, SHANG Jian, ZHOU Xiu-Zhong. Studies on Synthesis and Biological Activities of N-Silylmethyl-N-formyl Aniline Derivatives[J]. Chem. J. Chinese Universities, 1995, 16(6): 900.

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Studies on Synthesis and Biological Activities of N-Silylmethyl-N-formyl Aniline Derivatives

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