Determination of the Neurotransmitter in the Brain Using Composite Polymer Microelectrodes

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (12): 1847.

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Determination of the Neurotransmitter in the Brain Using Composite Polymer Microelectrodes

PENG Tu-Zhi¹, YANG Li-Ju¹, LI Hui-Ping¹, WANG Guo-Shun¹, HONG Jia-Qiong²

1. Department of Chemistry, Hangzhou University, Hangzhou, 310028;
2. Zhejiang Hospital

Received:1994-12-08 Revised:1995-03-30 Online:1995-12-24 Published:1995-12-24

Abstract

Abstract: A composite polymer carbon fiber electrode modified with Nafion and cellulose acetate is described.The incorporation of ion exchanging polymer to the cellulose acetate domain allows the binding of counterionic reactants, while maintaining the size exclusion discriminative properties of cellulose acetate.In vivo voltammetry,the modified microelectrode inhabits the oxidation of some neurotransmitter metabolites and electroactive compounds,such as DOPAC, 5-HIAA, HVA, AA and UA;and successfully detects the oxidative current of neurotransmitter DA.

Key words: Microelectrode, Chemically modified electrode, Voltammetry, Dopamine, Neurotransmitter

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PENG Tu-Zhi, YANG Li-Ju, LI Hui-Ping, WANG Guo-Shun, HONG Jia-Qiong. Determination of the Neurotransmitter in the Brain Using Composite Polymer Microelectrodes[J]. Chem. J. Chinese Universities, 1995, 16(12): 1847.

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Determination of the Neurotransmitter in the Brain Using Composite Polymer Microelectrodes

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