Studies on Structure-Activity Relationship of Acidic Hetero polysaccharide for Auricularia Auricula-Judae

Abstract

Abstract: The bioactivities for six fractionated and unfractionated samples of acidic heteropolysaccharide of Auricularia auricula-judae having different molecular weights (M_w and M_n) were studied. The results obtained by i. P. injection in mice show that the polysaccharides have bioactivities in motivating the growth of leucocytes, anticoagulation and decreasing blood platelet count, and the effects increase with the decrease of molecular weight and glucuronic acid content in the range(200×10⁴>M_w>18×10⁴; 16%>C_GA>9. 7%)studied.We conclude that the bioactivities depend seriously on the solubility of the polysacchride in water. In addtion, a method of acid-base back-titration used for determination of glucuronic acid content(C_GA) of the polysaccharides was established, and its experimental results are in good agreement with data in literature.

Key words: Auricularia auricula-judae polysaccharide, Bioactivity, Glucuronic acid analysis, Structure-activity relationship

TrendMD:

ZHANG Li-Na, CHEN He-Sheng, LI Xiang. Studies on Structure-Activity Relationship of Acidic Hetero polysaccharide for Auricularia Auricula-Judae[J]. Chem. J. Chinese Universities, 1994, 15(8): 1231.

[1]	ZHAO Yingzhe, ZHANG Jianling. Applications of Metal-organic Framework-based Material in Carbon Dioxide Photocatalytic Conversion [J]. Chem. J. Chinese Universities, 2022, 43(7): 20220223.
[2]	YANG Dan, LIU Xu, DAI Yihu, ZHU Yan, YANG Yanhui. Research Progress in Electrocatalytic CO₂ Reduction Reaction over Gold Clusters [J]. Chem. J. Chinese Universities, 2022, 43(7): 20220198.
[3]	ZHAO Mengyang, HUANG Ziyang. Preparation and in vitro Bioactivity of HA/CuO/SrCO₃ Gradiently Composite Coating [J]. Chem. J. Chinese Universities, 2022, 43(2): 20210644.
[4]	HOU Hua, WANG Baoshan. Group Additivity Theoretical Model for the Prediction of Dielectric Strengths of the Alternative Gases to SF₆ [J]. Chem. J. Chinese Universities, 2021, 42(12): 3709.
[5]	YE Xiaodong, QI Guodong, XU Jun, DENG Feng. Glucose Oxidation on Au-supported SBA-15 Molecular Sieve ^† [J]. Chem. J. Chinese Universities, 2020, 41(5): 960.
[6]	CHENG Qinwen, YUAN Bo, ZHU Xiangdong, ZHANG Kai, ZHANG Xingdong. Surface Elemental Compositions and in Vitro Bioactivities of the PEEK Materials with Various Sulfonation and Alkali Treatments [J]. Chem. J. Chinese Universities, 2019, 40(8): 1757.
[7]	CHANG Junpeng,ZHAO Jiarui,CHEN Sijia,MENG Kai,SHI Weini,LI Ruifang. Structure-activity Relationship of Antimicrobial Peptide SAMP1 and Its Analog Peptides^† [J]. Chem. J. Chinese Universities, 2019, 40(4): 705.
[8]	RUAN Xianghui, ZHAO Hongju, ZHANG Cheng, CHEN Lijuan, LI Pu, WANG Yihui, HE Ming, XUE Wei. Syntheses and Bioactivities of Myricetin Derivatives Containing Piperazine Acidamide Moiety^† [J]. Chem. J. Chinese Universities, 2018, 39(6): 1197.
[9]	YU Min, HUANG Jingjing, MA Min, FU Ruiyan, YAN Yan, ZHANG Fusheng, YIN Junfeng, XIE Ningning. Zinc Chelating Activity and Quantitative Structure-activity Relationship of Tripeptides^† [J]. Chem. J. Chinese Universities, 2018, 39(2): 234.
[10]	HOU Hua, YU Xiaojuan, ZHOU Wenjun, LUO Yunbai, WANG Baoshan. Theoretical Investigations on the Structure-activity Relationship to the Dielectric Strength of the Insulation Gases^† [J]. Chem. J. Chinese Universities, 2018, 39(11): 2477.
[11]	WANG Lei, ZHENG Guojun, JI Qi, CHEN Bo, GONG Longlong, GAO Congmin, DU Zhenjian, ZHANG Xingmin. Synthesis and Biological Activity of Novel PI3K/mTOR Inhibitors^† [J]. Chem. J. Chinese Universities, 2017, 38(9): 1590.
[12]	LIU Yuming, TIAN Lijun, HU Dong, NIE Jianbing. yntheses and Anti-cholinesterase Activity of 4-N-Phenylaminoquinoline Derivatives ^† [J]. Chem. J. Chinese Universities, 2017, 38(3): 392.
[13]	LIU Benguo, LIU Jiangwei, LI Jiaqi, GENG Sheng, MO Haizhen, LIANG Guizhao. 3D-QSAR and Interaction Mechanism of Flavonoids s P-glycoprotein Inhibitors^† [J]. Chem. J. Chinese Universities, 2017, 38(1): 41.
[14]	GUO Liang, CAO Rihui, FAN Wenxi, GAN Ziyun, MA Qin. Design, Synthesis and in vitro Antitumor Activities of Novel Bivalent β-Carbolines^† [J]. Chem. J. Chinese Universities, 2016, 37(6): 1093.
[15]	ZHANG Jie, ZHOU Changjian, XIE Jianwei, DAI Bin. Synthesis and Antitumor Activities of Rhein-Valine Adducts^† [J]. Chem. J. Chinese Universities, 2016, 37(12): 2159.

Studies on Structure-Activity Relationship of Acidic Hetero polysaccharide for Auricularia Auricula-Judae

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments