A New Approach to Selective Deoxygenation of Bile Acids

Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (10): 1494.

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A New Approach to Selective Deoxygenation of Bile Acids

LIKai-Xi, XU Zheng-Bang, YU Rui, ZHAO Hua-Ming

Department of Chemistry, Sichuan University, Chengdu, 610064

Received:1993-10-16 Revised:1994-08-03 Online:1994-10-24 Published:1994-10-24

Abstract

Abstract: Selective deoxygenation of four bile acids with K/18-Crown-6/Bu^t NH₂ was first reported.It can be accomplished by four steps:methylesterification, diacylation or selective diacylation, selective hydrolysis and reduction.The products formed in formal three steps were not isolated(not necessary).The last step is carried out rapidly at room temperature, with a little by-product.The present approach is straight forward, practicable and with high over all yields, 70% 75%.

Key words: Bile acids, Crown ether, Potassium, Deoxygenation, Radical

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LIKai-Xi, XU Zheng-Bang, YU Rui, ZHAO Hua-Ming. A New Approach to Selective Deoxygenation of Bile Acids[J]. Chem. J. Chinese Universities, 1994, 15(10): 1494.

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A New Approach to Selective Deoxygenation of Bile Acids

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