Syntheses and Bioactivities of 4H-1,2,4-triazol-4-yl Ketones and Alcohols

Chem. J. Chinese Universities ›› 1993, Vol. 14 ›› Issue (4): 517.

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Syntheses and Bioactivities of 4H-1,2,4-triazol-4-yl Ketones and Alcohols

LIAO Lian-An¹, CHEN Ming-De², ZHANG Hong-Kui², GUO Qi-Zhen²

1. Deft, of Chem., Xiamen Univ., Xiamen, 361005;
2. National Key Lab.of Elemento-Org.Chem., Nankai Univ.

Received:1992-07-05 Revised:1992-12-02 Online:1993-04-24 Published:1993-04-24

Abstract

Abstract: 1-(4H-1,2,4-Triazol-4-yl)pinacolone reacted with alkyl halide for 4 h under the condition of phase transfer catalysis to give 4H-1,2, 4-triazol-4-yl ketones (3) with the yields of 20%-93%.(3) were reduced by KBH₄ to afford the corresponding alcohols (4) with the yields of 92%-95%.The preliminary results of bioassay show that (3) and (4) have lower plant growth retarding and fungicidal activities than those of paclobutrazol.

Key words: 1-(4H-1,2,4-Triazol-4-yl)pinacolone, Alkylation, Reduction, Bioassay

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Syntheses and Bioactivities of 4H-1,2,4-triazol-4-yl Ketones and Alcohols

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