Chem. J. Chinese Universities ›› 1992, Vol. 13 ›› Issue (12): 1561.

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Synthesis of Spin-Labelled Anticancer Derivatives of 5-Fluorouracil

WANG Yan-Guang1, TIAN Xuan2, LI Jing-Xin2, CHEN Yao-Zu2   

  1. 1. Department of Chemistry, Tianjin University, Tianjin, 300072;
    2. Applied Organic Chemistry Laboratory, Lanzhou University, Lanzhou
  • Received:1992-04-01 Revised:1992-05-21 Online:1992-12-24 Published:1992-12-24

Abstract: Ten spin-labelled derivatives of 5-fluorouracil,as the potential anticancer agents,were synthesized.The structures of these new compounds were examined by IR,UV,MS,ESR and elementary analysis.The preliminary pharmacological tests show that some of the compounds possess anticancer activity against leukemia L1210 and utericervucak carcubbina U14 in mice.

Key words: Fluorouracil derivative, Anticancer activity, Spin label, Synthesis

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