Chem. J. Chinese Universities ›› 1990, Vol. 11 ›› Issue (5): 476.

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Application of Several Phosphorous Agents to the Preparation of Some Derivatives of 2-(4,5-Dihydro-4-Isopropyl-4-Methyl-5-Oxo-1H-Imidazoline-2-yl)-Benzoic Acid

Chen Ruyu, Liu Lijian   

  1. The Institute of Elemento-Organic Chemistry, Nankai University, Tianjin
  • Received:1989-02-04 Online:1990-05-24 Published:1990-05-24

Abstract: This paper is about the application of several phosphorous agents to the synthesis of somederivatives of 2-(4,5-dihydro-4-isopropyl-4-methyl-5-oxo-1H-imidazoline-2-yl)-benzoic acid( I ) .Ireacted with O,O-diethyl phosphorochloridothioic ester to give out a mixture of 1 : 1 of 2-oxo-3-isopropyl-3-methyl-3H-imidazoine[2,1-a]-1-oxo-isoindole and its isomer. But when I was stirredwith hexaalkyl phosphorous triamide in THF N,N-dialkyl amide of I was isolated.

Key words: Phosphorous agent, Cyclization, Amidation, Tautomerism

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