Chemical Journal of Chinese Universities ›› 2020, Vol. 41 ›› Issue (11): 2306-2323.doi: 10.7503/cjcu20200408

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Recent Advances of Exosomes Bioanalysis and Their Clinic Applications

ZHANG Yimeng1, ZHANG Huixin1,2, LIU Yang1()   

  1. 1.Department of Chemistry,Beijing Key Laboratory for Analytical Methods and Instrumentation,Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology of Ministry of Education,Tsinghua University,Beijing 100084,China
    2.Shandong Sino?Japanese Center for Collaborative Research of Carbon Nanomaterials,College of Chemistry and Chemical Engineering,Qingdao University,Qingdao 266071,China
  • Received:2020-06-30 Online:2020-11-10 Published:2020-11-06
  • Contact: LIU Yang
  • Supported by:
    supported by the National Key Research and Development Program of China(2016YFA0203101);the National Natural Science Foundation of China(21874080)


Exosomes are extracellular vesicles with various pivotal bioactive molecules such as lipids, proteins and nucleic acids. They are secreted by all types of cells and distributed in all biofluids, e.g. blood, saliva, sweat and urine. More importantly, the exosomes participate in multiple physiological activities including intercellular communication, mammalian reproduction and immune responses, and play the important role in the pathological progression including the metabolic and cardiovascular diseases, neurodegeneration and cancer, which make them the attractive natural non-invasive biomarkers, and are considered to be potential tools for the clinical diagnosis and therapy. In this review, we summarize the recent developments of biosensors for the detection of exosomes including series of methods such as fluorescence, electrochemistry, electrogenerated chemiluminescence, surface enhanced Raman spectra, colorimetry and microfluidic analysis. In addition, the clinic applications of exosomes were also described on the clinic diagnostic and diseases therapies. Finally, the challenges on the exosomes analysis as well as the potential researches on the clinic diagnostics and diseases therapies in the future were also discussed.

Key words: Exosomes, Biosensor, Quantitative analysis, Clinical application

CLC Number: