Recent Progress of Fluorescent Nanoprobes for Organelle pH Detection

doi:10.7503/cjcu20200279

Abstract

Abstract:

pH homeostasis plays a significant role in maintaining the normal functions of different organelles in living cells. The disruption of pH homeostasis will result in the disorder of organelle function and further lead to the relevant diseases, such as cancer, neurodegenerative disease, etc. Therefore, it is important to quantitively detect pH and monitor the fluctuation of organelle pH in living cells to explore the pathology of relevant diseases. Fluorescent probes are suitable for pH detection in living cell based on the advantages of noninvasive and high spatiotemporal resolution imaging. In this review, we summarized the recently developed fluorescent nanoprobes for the pH detection of different organelles. The chances and challenges of the practical application of fluorescent nanoprobes were also discussed.

Key words: Fluorescent nanoprobe, Organelles, pH, Detection, Imaging

CLC Number:

O657

TrendMD:

GONG Shaohua, ZHANG Xia, LI Na, TANG Bo. Recent Progress of Fluorescent Nanoprobes for Organelle pH Detection[J]. Chem. J. Chinese Universities, 2020, 41(9): 1933.

Figures/Tables 9

References 82

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