Chem. J. Chinese Universities ›› 2014, Vol. 35 ›› Issue (6): 1311.doi: 10.7503/cjcu20131185

• Physical Chemistry • Previous Articles     Next Articles

Idenpngication of Functional Residues in Maltose Transporter with the Elastic Network Model

ZHOU Xiaofeng1, XIE Xiaolu2, ZHANG Lei2, LI Chunhua2,*(), LOU Jiaoying3, LIU Naibo1, DING Zhenshan1,*()   

  1. 1. Department of Urology, China-Japan Friendship Hospital, Beijing 100029, China
    2. College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China
    3. Dong Fang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China
  • Received:2013-12-05 Online:2014-06-10 Published:2014-04-29
  • Contact: LI Chunhua,DING Zhenshan E-mail:chunhuali@bjut.edu.cn;dzsfighting@sina.com
  • Supported by:
    † Supported by the National Natural Science Foundation of China(No.31171267), the Project of Beijing Municipal Education Commission, China(No.KM201310005030), the Science and Technology Innovation Platform of Beijing Municipal Education Commission and Wu Jie Ping Medical Foundation, China(No.320.6750.12703)

Abstract:

Maltose transporter is an important kind of transmembrane transporters with significant biological functions which bears the transportation of intracellular and extracellular maltose molecules. The transport process of maltose molecule accompanies with large scale cooperative motions between different domains of maltose transporter. And these motions involve some key residues that mediate signal transduction and allosteric effects between different regions of the protein. In this study, we idenpngied the key residues in this protein system with the thermodynamic method based on the elastic network model which was developed by our group. On this basis, we explored the long-range synergies within the maltose transporter. These results are helpful to a better understanding the molecular mechanisms of function of transporters.

Key words: Maltose transporter, Elastic network model, Thermodynamic cycle, Allosteric effect, Functional residue

CLC Number: 

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