Chem. J. Chinese Universities ›› 2012, Vol. 33 ›› Issue (11): 2435.doi: 10.7503/cjcu20111145

• Analytical Chemistry • Previous Articles     Next Articles

Rapid Direct Method for Determination of lgP Value by Dispersive Liquid/liquid Microextraction

FU Hua-Feng1, WANG Li-Na1, FAN Chun-Ying2, LI Xiao-Meng1   

  1. 1. College of Chemistry and Chemical Engineering, Xuchang University, Xuchang 461000, China;
    2. Department of Chemistry, Zhengzhou University, Zhengzhou 450052, China
  • Received:2011-12-02 Online:2012-11-10 Published:2012-10-15

Abstract:

A novel and rapid direct method was developed for the determination of lgP value by dispersive liquid/liquid microextraction(DLLME). The equilibrium of test compound between the two phases was reached in less than 3 min and the two phases were separated quickly by an ultrastrong magnet. Moreover, interruption of absorption of Fe3O4/SiCH2CH3Cl with the partition equilibrium of test compound was negligible because a thick layer 1-octanol was surrounded around their surfaces. The novel method was evaluated with 14 reference compounds and shown to be suitable for accurate determination of lgP value and the upper limit of lgP range was high. This direct method was very quick, accurate and small amount of sample consuming.

Key words: 1-Octanol-water partition coefficient, lgP value, Dispersive liquid/liquid microextraction, High performance liquid chromatography

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