Investigation of Interaction of Fangchinoline with G-quadruplex DNA by Electrospray Ionization Mass Spectrometry

doi:10.7503/cjcu20111169

Chem. J. Chinese Universities ›› 2012, Vol. 33 ›› Issue (11): 2430.doi: 10.7503/cjcu20111169

• Analytical Chemistry • Previous Articles Next Articles

Investigation of Interaction of Fangchinoline with G-quadruplex DNA by Electrospray Ionization Mass Spectrometry

XU Niu-Sheng^1,2, YANG Hong-Mei^1,2, CUI Meng¹, SONG Feng-Rui¹, LIU Zhi-Qiang¹, LIU Shu-Ying^1,3

1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China;
2. Graduate School of the Chinese Academy of Sciences, Beijing 100049, China;
3. Institute of Ginseng Research, Changchun University of Chinese Medicine, Changchun 130117, China

Received:2011-12-12 Online:2012-11-10 Published:2012-10-15

Abstract

Abstract:

Electrospray ionization mass spectrometry (ESI-MS) was used to investigate the interaction of fangchinoline with G-quadruplex and duplex DNA. The results showed that fangchinoline selectively bound to G-quadruplex DNA. Upon MS/MS experiments, complexes of fangchinoline and G-quadruplex DNA underwent the loss of fangchinoline, suggesting an end-stacking binding mode, while complexes of fangchinoline and duplex DNA underwent the loss of fangchinoline, suggesting the intercalated binding mode.

Key words: Electrospray ionization mass spectrometry(ESI-MS), Duplex DNA, G-quadruplex, Fangchinoline, Interaction

CLC Number:

O657.63

TrendMD:

XU Niu-Sheng, YANG Hong-Mei, CUI Meng, SONG Feng-Rui, LIU Zhi-Qiang, LIU Shu-Ying. Investigation of Interaction of Fangchinoline with G-quadruplex DNA by Electrospray Ionization Mass Spectrometry[J]. Chem. J. Chinese Universities, 2012, 33(11): 2430.

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Investigation of Interaction of Fangchinoline with G-quadruplex DNA by Electrospray Ionization Mass Spectrometry

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