Light Induced Cellular Cytotoxicity of Rich Arginine Peptide Modified Ferric Oxide Core Gold Shell Nanoparticles

doi:10.3969/j.issn.0251-0790.2012.09.008

Abstract

Abstract:

The laser induced cellular cytotoxicity of rich arginine peptide RRRRRRRR(R₈) modified ferric oxide core gold shell nanoparticles(R₈-Fe₂O₃@Au NP) was studied. Although R₈-Fe₂O₃@Au NP has a low cytotoxicity, the viability of nanoparticles internalized HeLa cell can be decreased by laser irradiation. The experimental result indicates that the R₈-Fe₂O₃@Au NPs have significant cellular phototoxicity under laser irradiation. In addition, the cellular phototoxicity of R₈-Fe₂O₃@Au NPs is dependent on the wavelength of irradiation laser, and increased by the irradiating time and light intensity.

Key words: Fe₂O₃@Au nanoparticles, Peptide, Phototoxicity, Living cell

CLC Number:

O611.4

TrendMD:

LIU Gui-Feng, GAO Zhong-Li, YU Qiong, ZHANG Hui-Mao, WANG Zhen-Xin. Light Induced Cellular Cytotoxicity of Rich Arginine Peptide Modified Ferric Oxide Core Gold Shell Nanoparticles[J]. Chem. J. Chinese Universities, 2012, 33(09): 1920.

References

[1] MA Li-Na(马立娜), LIU Dian-Jun(刘殿骏), WANG Zhen-Xin(王振新). Chin. J. Anal. Chem.(分析化学)[J], 2010, 38(1): 1-7

[2] Sepúlveda B., Angelomé P. C., Lechuga L. M., Liz-Marzán L. M.. Nano Today[J], 2009, 4: 244-251

[3] Rosi N. L., Mirkin C. A.. Chem. Rev.[J], 2005, 105: 1547-1562

[4] Deng X. Y., Gao D. J., Tian Y., Chen Y. H., Yu A. M., Zhang H. Q., Wang X. H., Chen Y.. Chem. Res. Chinese Universities[J], 2010, 26(1): 23-26

[5] Teng H., Liu Y., You T. Y.. Chem. Res. Chinese Universities[J], 2011, 27(3): 496-499

[6] Lewin M., Carlesso N., Tung C. H., Tang X. W., Cory D., Scadden D. T., Weissleder R.. Nat. Biotechnol.[J], 2000, 18: 410-414

[7] Bulte J. W. M., Douglas T., Witwer B., Zhang S. C., Strable E., Lewis B. K., Zywicke H., Miller B., Gelderen P. V., Moskowitz B. M., Duncan L. D., Frank J. A.. Nat. Biotechnol.[J], 2001, 19: 1141-1147

[8] Bao J., Chen W., Liu T., Zhu Y., Jin P., Wang L., Liu J., Wei Y., Li Y.. ACS Nano[J], 2007, 1: 293-298

[9] Sun L., Wang J., Wang Z.. Nanoscale[J], 2010, 2: 269-276

[10] Zhang J. L.,Tan X. C., Zhao D. D., Tan S. W., Li L., Wang L., Huang Z. W.. Chem. Res. Chinese Universities[J], 2011, 27(4): 566-569

[11] Yang P., Xu Q. Z., Jin S. Y., Zhao Y., Lu Y., Xu X. W., Yu S. H.. Chem. Eur. J.[J], 2012, 18: 1154-1160

[12] Nikolai K., Lev D.. Chem. Soc. Rev.[J], 2011, 40: 1647-1671

[13] Won J. N., Jin H., Chung H., Kim S.. J. Am. Chem. Soc.[J], 2009, 131: 13639-13645

[14] Lee S. M., Park H., Choi J. W., Park Y. N., Yun C. O., Yoo K. H.. Angew. Chem. Int. Ed.[J], 2011, 50: 7581-7586

[15] Huang X. H., El-Sayed I. H., Qian W., El-Sayed M. A.. J. Am. Chem. Soc.[J], 2006, 128: 2115-2120

[16] Hirsch L. R., Stafford R. J., Bankson J. A., Sershen S. R., Rivera B., Price R. E., Hazle J. D., Halas N. J., West J. L.. Proc. Natl. Acad. Sci. USA[J], 2003, 100: 13549-13554

[17] Levy R., Thanh N. T. K., Doty R. C., Hussain I., Nichols R. J., Schiffrin D. J., Brust M., Fernig D. G.. J. Am. Chem. Soc[J], 2004, 126: 10076-10084

[18] Lyon J. L., Fleming D. A., Stone M. B., Schiffer P., Williams M. E.. Nano Lett.[J], 2004, 4: 719-723

[19] Mosmann T.. J. Immunol. Methods[J], 1983, 65: 55-63

[20] Sun L., Liu D., Wang Z.. Langmuir[J], 2008, 24: 10293-10297

[21] Lewinski N., Colvin V., Drezek R.. Small[J], 2008, 4: 26-49