高等学校化学学报

高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (10): 1473.

• 论文 • 上一篇    下一篇

不对称环磷化合物的合成及立体化学(Ⅰ)─环磷酰氯和3－羟基异噁唑的反应及其立体化学

邵瑞链, 杨敏华, 职承信   

  1. 南开大学元素有机化学研究所, 天津, 300071
  • 收稿日期:1993-11-27 修回日期:1994-03-04 出版日期:1994-10-24 发布日期:1994-10-24
  • 通讯作者: 邵瑞链,女,55岁,教授.
  • 作者简介:邵瑞链,女,55岁,教授.

Synthesis and Stereochemistry of 4-Substitutedphenyl -1,3,2-dioxaphosphorin Compounds(Ⅰ)─Reaction and Stereochemistry of Cyclic Phosphorochloridates and 3-Hydroxyisoxazole

SHAO Rui-Lian, YANG Min-Hua, ZHI Cheng-Xin   

  1. Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071
  • Received:1993-11-27 Revised:1994-03-04 Online:1994-10-24 Published:1994-10-24

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摘要： 研究了2-氧代-2-氯-4-取代苯基-5,5-二甲基-1,3,2-二氧磷杂环己烷与3-羟基异唑的反应,得到的氧磷酰化产物含有顺反两种异构体,用1HNMR、31PNMR、X射线衍射确定了它们的构型,并讨论了亲核取代反应中手性磷原子构型保持和翻转的机理,测定了异构体的生物活性。

关键词: 1, 3, 2－二氧磷杂环, 顺反异构体, 立体化学

Abstract: Owing to the biological activities of 3-hydroxyisoxazole and cyclic phosphate derivatives, some compounds possessing the two moieties were synthesized, the structural elucidation of these diastereomers was made depending on spectral analyses.The mechanism could be illustrated by the theories of trigonal bipyramide intermediate and pseudorotation.

Key words: dioxaphosphorin, Cis-trans isomers, Stereochemistry

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