高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (10): 1577.

• 论文 • 上一篇    下一篇

N-芳基-异丙胺甲酰基膦酰胺甲酯的研究

陈茹玉, 李慧英, 任康太   

  1. 南开大学元素有机化学研究所, 天津, 300071
  • 收稿日期:1994-10-14 修回日期:1995-03-22 出版日期:1995-10-24 发布日期:1995-10-24
  • 通讯作者: 陈茹玉,女,74岁,教授,博士生导师.
  • 作者简介:陈茹玉,女,74岁,教授,博士生导师.
  • 基金资助:

    国家自然科学基金

Studies on N-Aryl-isopropyl-carbamoyl Methyl Phosphonamidate

CHEN Ru-Yu, LI Hui-Ying, REN Kang-Tai   

  1. Elemento-org. Chem. Institute, Nankai Univ. Tianjin, 300071
  • Received:1994-10-14 Revised:1995-03-22 Online:1995-10-24 Published:1995-10-24

PDF (PC)

被引次数

1

关键词: 膦酰胺, 氨基甲酰基膦酸酯, 氢键

Abstract: Eight of the title compounds, N-aryl-isopropyl-carbamoyl methyl phosphonamidate(Ⅰ)(i-prNHC(O)P(O)(OMe)NHAr, Ar=substituted phenyl, substituted pyridyl),were synthesized by reacting the phosphonyl chloride with arylamine under a mild condition in order to study the method of the synthesis of this kind of compounds and look for efficient antiviral drugs and pesticides. The preliminary bioassay showed that the title compounds had little bioactivity. The structure of the compounds had been studied and 1HNMR showed that there were two kinds of inter-molecular hydrogen bondings in the compounds.

Key words: Phsophonamidate, Carbamoylphosphonate, Hydrogen bonding

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