高等学校化学学报

高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (10): 1882.

• 研究论文 • 上一篇    下一篇

含有1H-1,2,4-三唑咪唑[2,1-b]-1,3,4-噻二唑、S-三唑[3,4-b]-1,3,4-噻二唑衍生物的合成及生物活性

张艳1, 刘东1, 戴朝峰1, 张自义1, 许鹏飞1, 惠新平1, 王勤2   

  1. 1. 兰州大学化学化工学院, 应用有机化学国家重点实验室;
    2. 兰州大学生命科学学院, 兰州 730000
  • 收稿日期:2001-07-17 出版日期:2002-10-24 发布日期:2002-10-24
  • 通讯作者: 张自义(1933年出生),男,教授,博士生导师,从事杂环化学研究.许鹏飞(1964年出生),男,博士,硕士生导师,主要从事杂环化学研究.
  • 基金资助:

    国家自然科学基金(批准号:QTProgram)资助

Synthesis and Biological Activities of Imidazolo[2,1-b]-1,3,4-thiadiazole,S-Triazole[3,4-b]-1,3,4-thiadiazole Derivatives Bearing 1H-1,2,4-triazole

ZHANG Yan1, LIU Dong1, DAI Chao-Feng1, ZHANG Zi-Yi1, XU Peng-Fei1, HUI Xin-Ping1, WANG Qin2   

  1. 1. National Laboratory of Applied Organic Chemistry, College of Chemistry and Engineering, Lanzhou University;
    2. College of Lif e Science, Lanzhou University, Lanzhou 730000, China
  • Received:2001-07-17 Online:2002-10-24 Published:2002-10-24

PDF (PC)

被引次数

36

摘要： 合成了18个含有1H-1,2,4-三唑的咪唑[2,1-b]-1,3,4-噻二唑以及S-三唑[3,4-b]-1,3,4-噻二唑的稠杂环衍生物,经元素分析及谱学表征,探讨2,5,6-三取代咪唑[2,1-b]-1,3,4-噻二唑的可能生成机制.对大肠杆菌、绿脓杆菌、枯草杆菌等初步抑菌试验证明,多数化合物表现了较好的抑菌活性.

关键词: 1H-1, 2, 4-三唑, 咪唑[2, 1-b]-1, 3, 4-噻二唑, S-三唑[3, 4-b]-1, 3, 4-噻二唑, 抑菌活性

Abstract: Eighteen novel imidazolo-1,3,4-thiadiazoles and S-triazole-1,3,4-thiadiazoles containing 1H-1,2,4-triazole were synthesized and their structures were confirmed by elemental analyses and spectral analysis. And the characteristic data of 1H NMR and MS were explained reasonably. Furthermore, we also proposed the synthetic mechanism of 2,5,6-substituted-imidazolo-1,3,4-thiadiazole. Primary antibacterial test against E.coli, P.aeruginosa, B.subtilis and S.aureus showed that most of them had good antibacterial activities.

Key words: 1H-1,2,4-Triazole, Imidazolo[2,1-b]-1,3,4-thiadiazole, S-triazole[3,4-b]-1,3,4-thiadiazole, Antibacterial activities

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