高等学校化学学报 ›› 2012, Vol. 33 ›› Issue (02): 416.doi: 10.3969/j.issn.0251-0790.2012.02.036

• 高分子化学 • 上一篇    下一篇

末端为磷酰胆碱基团的聚丁二酸丁二醇酯的酶促降解和热性能

张世平, 王丹, 党媛, 史素青, 宫永宽   

  1. 合成与天然功能分子化学教育部重点实验室, 西北大学化学与材料科学学院, 西安 710069
  • 收稿日期:2011-03-10 出版日期:2012-02-10 发布日期:2012-01-13
  • 通讯作者: 宫永宽, 男, 博士, 教授, 主要从事生物医用材料仿细胞膜结构改性研究. E-mail: gongyk@nwu.edu.cn E-mail:gongyk@nwu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号: 21004048, 20974048)和陕西省教育厅基金(批准号: 2010JK886)资助.

Enzymatic Biodegradation and Thermal Properties of Phosphorylcholine Functionalized Poly(butylene succinate)

ZHANG Shi-Ping, WANG Dan, DANG Yuan, SHI Su-Qing, GONG Yong-Kuan   

  1. Key Laboratory of Synthetic and Natural Functional Molecule Chemistry, Ministry of Education, College of Chemistry & Materials Science, Northwest University, Xi'an 710069, China
  • Received:2011-03-10 Online:2012-02-10 Published:2012-01-13

摘要: 以聚丁二酸丁二醇酯(PBS)为参照, 研究了酯酶Lipase AY30对亲水磷酰胆碱(PC)基团改性的聚丁二酸丁二醇酯(PBS-PC)的生物降解性能的影响. 结果显示, 在酯酶Lipase AY30作用下, 21 d后PBS的质量损失仅为1.9%, 而PBS-PC的质量损失了9.7%. 相同条件下扣除各自水解引起的质量损失(PBS 1.4%和PBS-PC 6.5%)后, PC亲水基团的引入对聚合物的降解起到了促进作用. 示差扫描量热(DSC)研究结果表明, 改性后的聚合物熔融温度和熔融焓降低, 玻璃化转变温度升高, 表明PC端基的引入降低了PBS的结晶能力, 非晶相结构的增多对聚合物降解有促进作用. 因此PBS-PC有望作为一种新的具有良好生物降解性和生物相容性的高分子材料, 应用于药物控释、基因治疗及组织工程等生物医用材料领域.

关键词: 酯酶Lipase AY30, 酶促降解, 聚丁二酸丁二醇酯, 磷酰胆碱, 热性能

Abstract: Enzymatic degradation of poly(butylene succinate)(PBS) and phosphorylcholine functionalized poly(butylene succinate)(PBS-PC) were performed in the presence of lipase AY30. It was found that PBS-PC was effectively biodegraded by lipase AY30, and PBS was hardly degraded even after an experimental time scale of 21 d. By means of differential scanning calorimetry(DSC), thermal properties of PBS and PBS-PC were studied. The results show that the melting point(Tm) of PBS-PC is decreased and glass transition tempe-rature(Tg) is increased compared with unmodified PBS. PBS-PC may have potential applications in biological environments as new carriers for controlled drug release, gene therapy, and scaffold for tissue engineering systems.

Key words: Lipase AY30, Enzymatic degradation, Poly(butylene succinate), Phosphorylcholine, Thermal stability

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