高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    

新型Src激酶抑制剂对APP/PS1小鼠的神经保护作用的研究

罗蕊1,张芯玮1,刘洋1,王磊1,吴小君1,肖军海2,林凤1   

  1. 1. 吉林大学生命科学学院

    2. 中国人民解放军军事科学院军事医学研究院

  • 收稿日期:2026-06-21 修回日期:2026-07-22 出版日期:2026-07-28 发布日期:2026-07-28
  • 通讯作者: 林凤 E-mail: linfeng@jlu.edu.cn
  • 基金资助:

    中国吉林省科技厅自然科学基金会（批准号：20220101268JC）资助

Neuroprotective Effects of Novel Src Kinase Inhibitor on APP/PS1 Mice

Rui Luo1, Xinwei Zhang1, Yang Liu1, Lei Wang 1, Xiaojun Wu1, Junhai Xiao2, Feng Lin1   

  1. 1. School of Life Sciences, Jilin University
    2. Academy of Military Medical Sciences, Academy of Military Sciences
  • Received:2026-06-21 Revised:2026-07-22 Online:2026-07-28 Published:2026-07-28
  • Contact: Feng Lin E-mail: linfeng@jlu.edu.cn
  • Supported by:

    Supported by the Natural Science Foundation of Science and Technology Agency of Jilin Province of China (No. 20220101268JC)

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摘要：

该研究旨在探讨Src酪氨酸蛋白激酶抑制剂（Y-11）对转基因小鼠APP/PS1的神经保护作用. 研究中，Y-11的给药可以显著改善阿尔茨海默病（AD）小鼠认知功能障碍，同时降低大脑中AD病理相关蛋白的表达. 同时，Y-11通过抑制胶质细胞激活，增加突触蛋白水平，减轻神经炎症并缓解突触功能的障碍. 总之，我们的研究表明Y-11对AD的神经保护作用，为未来Src抑制剂治疗AD提供了理论基础.

关键词:

Src激酶抑制剂, 阿尔茨海默病, 1,3-硒唑-5-甲酰胺衍生物

Abstract: This study aimed to investigate the neuroprotective effects of the Src tyrosine kinase inhibitor Y-11 in transgenic APP/PS1 mice. Mice administrated with Y-11 could significantly improve cognitive deficits in Alzheimer’s disease (AD) and reduce the expressions of AD-related pathological proteins in the brain. Meanwhile, Y-11also attenuated neuroinflammation and synaptic dysfunction by inhibiting glial cell activation, and restored synaptic protein levels. In summary, the results suggested that Y-11 had neuroprotective effects on AD mice, provided a theoretical basis on the potential therapeutic application of Src kinase inhibitors in Alzheimer’s disease.

Key words:

Src kinase inhibitors, Alzheimer’s disease, 1,3-selenazole-5-formamide derivates

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