高等学校化学学报

高等学校化学学报

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垂直有序介孔二氧化硅薄膜在电致化学发光生物传感研究进展

李维鑫1,4，曾玉岚2，彭志鸿1,4，陈展飞3,4，李金秋1,4，陈仲辉1,4,林振宇2
  

  1. 1. 莆田学院附属医院，中心实验室 2. 福州大学化学学院，食品安全与生物分析教育部重点实验室，福建省食品安全分析与检测重点实验室 3. 莆田学院附属医院，检验科 4. 莆田学院药学与医学技术学院，医学微生态学福建省高校重点实验室
  • 收稿日期:2026-01-28 修回日期:2026-03-18 出版日期:2026-03-25 发布日期:2026-03-25
  • 通讯作者: 林振宇 E-mail:zylin@fzu.edu.cn
  • 基金资助:
    国家自然科学基金（批准号: 82204102）, 福建省自然科学基金（批准号: 2025J011530）, 福建省卫生健康科技计划项目(批准号: 2025QN01010039)和莆田市科技计划项目(批准号：2025NJYL090、2025NJYL082)资助

Research Advances in Vertically-Ordered Mesoporous Silica Films for Electrochemiluminescence Biosensing

Li Weixin1,4, Zeng Yulan2, Peng Zhihong1,4, Chen Zhanfei3,4, Li Jinqiu1,4, Chen Zhonghui1,4, Lin Zhenyu2   

  1. 1. Central Laboratory, Affiliated Hospital of Putian University 2. Fujian Provincial Key Laboratory of Analysis and Detection for Food Safety, Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry, Fuzhou University 3. Department of Laboratory Medicine, Affiliated Hospital of Putian University 4. Fujian Province University Key Laboratory of Medical Microecology, Pharmaceutical and Medical Technology College, Putian University
  • Received:2026-01-28 Revised:2026-03-18 Online:2026-03-25 Published:2026-03-25
  • Contact: Lin ZhenYu E-mail:zylin@fzu.edu.cn
  • Supported by:
    Supported by the National Natural Science Foundation of China (No. 82204102), the Natural Science Foundation of Fujian Province，China(No. 2025J011530), the Project Sponsored by Fujian Provincial Health Technology, China (No. 2025QN01010039) and the Science and Technology Project of Putian, China (Nos. 2025NJYL090, 2025NJYL082)

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摘要： 电致化学发光（Electrochemiluminescence, ECL）生物传感因高灵敏度、低背景信号和优良的可控性，在生物医学分析和临床诊断中展现出显著的应用潜力。然而，传统界面材料组装时普遍面临信号分子易泄漏、抗生物污染能力不足和痕量目标物信号放大能力有限等问题。垂直有序介孔二氧化硅薄膜（Vertically-ordered Mesoporous Silica Film, VMSF）作为一种新型纳米结构材料，凭借其高度有序、垂直排列的纳米通道结构，独特的尺寸筛分效应、电荷选择性、高比表面积以及易修饰性，为构建新一代高性能ECL生物传感提供了理想界面。本文探讨VMSF的结构特性、主要制备方法及在ECL生物传感中的界面功能化组装策略，总结VMSF在小分子、肿瘤标志物、核酸、药物及细胞检测等领域的最新应用进展。最后，结合当前研究面临的挑战，展望基于VMSF的ECL生物传感未来研究方向。

关键词: 垂直有序介孔二氧化硅薄膜, 生物传感, 电致化学发光, 纳米通道

Abstract: Electrochemiluminescence (ECL) biosensing technology demonstrates significant potential in biomedical analysis and clinical diagnosis due to its high sensitivity, low background signal, and excellent controllability. However, traditional materials were commonly confronted problems such as easy leakage of signal molecules, insufficient anti-biocontamination ability, and limited signal amplification capacity for trace target substances during ECL biosening interface assembly. The vertically-ordered mesoporous silica film (VMSF), as a novel nanostructured material, offers an ideal interface for constructing a new generation of high-performance ECL biosensing by virtue of its highly ordered, vertically arranged nano-channel structure, unique size sieving effect, charge selectivity, high specific surface area, and facile modifiability. This review comprehensively outlines the structural characteristics and preparation methods of VMSF, and the functionalization assembly strategies of VMSF interface in ECL biosensing. Then, the latest application progress of VMSF in the detection of small molecules, tumor markers, nucleic acids, drugs, and cells are systematically summarized. Finally, current challenges and future research directions are discussed, aiming to provide insightful perspectives for the rational design of ECL biosensing based on VMSF.

Key words: Vertically-ordered mesoporous silica film, Biosensing; Electrochemiluminescence, Nanochannels

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