高等学校化学学报 ›› 2019, Vol. 40 ›› Issue (6): 1128.doi: 10.7503/cjcu20190006
收稿日期:
2019-01-04
出版日期:
2019-06-10
发布日期:
2019-05-11
作者简介:
联系人简介: 黄池宝, 男, 博士, 教授, 主要从事双光子荧光探针方面的研究. E-mail:
基金资助:
HUANG Chibao(), PAN Qi, CHEN Huashi, LIANG Xing, LÜ Guoling
Received:
2019-01-04
Online:
2019-06-10
Published:
2019-05-11
Supported by:
摘要:
构建了一个衍生于双氰基二苯代乙烯的具有推-拉电子结构的环境敏感探针(SP), 该探针可作为将溶剂生色与分子转子特性结合起来的一个典型范例. SP探针的最大发射波长随溶剂极性的增加而显著增大, 归根于激发态分子转化为一个或多个扭转分子内电荷迁移(TICT)态, 极性溶剂更有利于电荷分离态分子的稳定. 在TICT态, 分子的荧光量子产率强烈地依赖于溶剂的极性、 黏度与温度. SP探针显示了很宽的溶剂生色范围, 在环己烷和二甲亚砜中的最大发射波长(λem)分别为445和641 nm, 相差196 nm, 能用于溶剂极性、 溶剂种类、 黏度与温度的检测识别. SP探针在环己烷和N,N-二甲基甲酰胺中的双光子吸收截面分别为5560和130 GM, 远高于同类双光子荧光探针; 其超大的斯托克斯位移(232 nm)可显著降低吸收谱对荧光的干扰, 显示出优良的检测成像性能, 可用于细胞黏度实时动态显微成像.
中图分类号:
TrendMD:
黄池宝, 潘淇, 陈华仕, 梁兴, 吕国岭. 双氰基二苯代乙烯型双光子荧光环境敏感探针. 高等学校化学学报, 2019, 40(6): 1128.
HUANG Chibao,PAN Qi,CHEN Huashi,LIANG Xing,LÜ Guoling. Dicyanostilbene-derived Two-photon Fluorescence Environment-sensitive Probe†. Chem. J. Chinese Universities, 2019, 40(6): 1128.
Fig.1 Correlations between the emission maxima of SP in various solvents and selected solvent parameters such as Δf, π*, δΔG≠, ET(30) and Z c(SP)=1 μmol/L, λex(OP)=410 nm.
Fig.4 Normalized emission spectra of SP in ethanol at different temperatures c(SP)=3.6 μmol/L, λex(OP)=410 nm, a. 77 K; b. 77—294 K; c. 294 K. No control of the temperature was available when samples at 77 K were warmed up. The exact temperature of spectrum B was unknown, visual inspection showed that was mostly a solution.
Fig.7 Bright-field(A) and two-photon microscopy(TPM, B) image 1 μmol/L SP-labeled mouse fibroblast two-photon fluorescent images were collected at 550—650 nm, λex=790 nm, replicate experiments 5 times.
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