高等学校化学学报 ›› 2020, Vol. 41 ›› Issue (2): 191-203.doi: 10.7503/cjcu20190614

• 庆祝《高等学校化学学报》复刊40周年专栏 • 上一篇    下一篇

可双光子激发的聚集诱导发光光敏剂及其生物医学应用

武文博,刘斌()   

  1. 新加坡国立大学, 化学工程与分子生物工程系, 新加坡 117585
  • 收稿日期:2019-11-26 出版日期:2020-02-10 发布日期:2019-12-31
  • 通讯作者: 刘斌 E-mail:chewwe@nus.edu.sg
  • 基金资助:
    Singapore National Research Foundation Competitive Research Program(No.R279-000-483-281);National Research Foundation Investigatorship(No.R279-000-444-281);the National University of Singapore资助(No.R279-000-482-133)

Two-photon Excitable Photosensitizers with Aggregation-induced Emission and Their Biomedical Applications

WU Wenbo,LIU Bin()   

  1. Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore 117585, Republic of Singapore
  • Received:2019-11-26 Online:2020-02-10 Published:2019-12-31
  • Contact: Bin LIU E-mail:chewwe@nus.edu.sg
  • Supported by:
    ? Supported by the Singapore National Research Foundation Competitive Research Program(No.R279-000-483-281);the National Research Foundation Investigatorship(No.R279-000-444-281);the National University of Singapore(No.R279-000-482-133)

摘要:

综合评述了双光子激发的聚集诱导发光(AIE)光敏剂的研究进展, 重点讨论了双光子激发的AIE光敏剂的设计思路及在生物医学中的应用, 并对其发展前景进行了展望.

关键词: 聚集诱导发光, 光敏剂, 光动力治疗, 双光子激发

Abstract:

The concept of two-photon excited photodynamic therapy based on photosensitizers with aggregation-induced emission(AIE) takes advantages of high penetration depth and precision from two-photon technology, and high photosensitization efficiency in aggregate state from AIE photosensitizers. In this contribution, we review the recent progress in this field, which includes the design principles of two-photon excitable AIE photosensitizers, specific examples of AIE photosensitizers and their biomedical applications. The perspectives for the future development of this field was also discussed.

Key words: Aggregation-induced emission, Photosensitizer, Photodynamic therapy, Two-photon excitation

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