高等学校化学学报 ›› 2017, Vol. 38 ›› Issue (9): 1639-1644.doi: 10.7503/cjcu20170057

• 物理化学 • 上一篇    下一篇

单十二烷基磷酸酯辅助共轭亚油酸的囊泡化研究

梁潇丹, 樊晔, 方云(), 夏咏梅, 程若辉   

  1. 江南大学化学与材料工程学院, 合成与生物胶体教育部重点实验室, 无锡 214122
  • 收稿日期:2017-01-23 出版日期:2017-09-10 发布日期:2017-08-22
  • 作者简介:联系人简介: 方 云, 男, 博士, 教授, 博士生导师, 主要从事胶体与界面化学方面的研究. E-mail: yunfang@126.com
  • 基金资助:
    国家重点研发计划项目(批准号: 2017YFB0308705)、 国家自然科学基金(批准号: 21276113, 21606107)和江苏省高等学校大学生创新创业训练计划项目(批准号: 201610295051X)资助

Investigation of Vesiculation of Conjugated Linoleic Acid Assisted by Monolauryl Phosphate

LIANG Xiaodan, FAN Ye, FANG Yun*(), XIA Yongmei, CHENG Ruohui   

  1. Key Laboratory of Synthetic and Biological Colloids(Ministry of Education),School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China
  • Received:2017-01-23 Online:2017-09-10 Published:2017-08-22
  • Contact: FANG Yun E-mail:yunfang@126.com
  • Supported by:
    † Supported by the National Key R&D Program of China(No.2017YFB0308705), the National Natural Science Foundation of China(Nos.21276113, 21606107) and the Undergraduate Innovation and Entrepreneurship Training Program of Jiangsu Province of China(No.201610295051X)

摘要:

以共轭亚油酸(CLA)为模型脂肪酸, 与安全、 温和的阴离子表面活性剂单十二烷基磷酸酯(MLP)进行复配, 动态激光光散射和透射电镜表征结果表明, CLA在中性至弱酸性环境中仍然能够囊泡化. 通过pH滴定曲线研究了CLA和MLP 2种分子的荷电物种随pH值的变化规律, 据此分析各物种间的相互作用, 并推断经MLP辅助CLA能够在中性至弱酸性环境中囊泡化的动因是CLA-MLP间的氢键或离子-偶极作用.

关键词: 脂肪酸囊泡, 囊泡化, pH窗口, 单十二烷基磷酸酯, 共轭亚油酸

Abstract:

A safe and mild anionic surfactant monolauryl phosphate(MLP) was blend with conjugated linoleic acid(CLA) that acted as the model fatty acid, and the vesiculation of CLA was observed in the weakly acidic to neutral pH range by DLS and TEM. Various charged species of the above two molecules with pH variation were investigated by means of pH titration, and molecular interaction among these species was reasoned. The impetus driving vesiculation of CLA assisted by MLP in the weakly acidic to neutral pH range was ascribed to hydrogen bonding and ion dipole interaction between CLA and MLP.

Key words: Fatty acid vesicle, Vesiculation, pH window, Monolauryl phosphate, Conjugated linoleic acid

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