高等学校化学学报 ›› 2019, Vol. 40 ›› Issue (6): 1193-1200.doi: 10.7503/cjcu20190084

• 物理化学 • 上一篇    下一篇

高内相/自乳液聚合的共轭亚油酸低聚体的囊泡化及稳定性

樊晔, 刘婷婷, 方云(), 夏咏梅   

  1. 江南大学化学与材料工程学院, 合成与生物胶体教育部重点实验室, 无锡 214122
  • 收稿日期:2019-01-29 出版日期:2019-06-10 发布日期:2019-05-11
  • 作者简介:

    联系人简介: 方 云, 男, 博士, 教授, 博士生导师, 主要从事胶体与界面化学方面的研究. E-mail: yunfang@126.com

  • 基金资助:
    国家重点研发计划项目(批准号: 2017YFB0308705)资助.

Vesiculation and Stability: Oligomer of Conjugated Linoleate Acids Prepared by High Internal Phase Self-emulsion Polymerization

FAN Ye, LIU Tingting, FANG Yun(), XIA Yongmei   

  1. Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China
  • Received:2019-01-29 Online:2019-06-10 Published:2019-05-11
  • Supported by:
    †Supported by the National Key Research and Development Program of China(No.2017YFB0308705).

摘要:

采用自乳化法制备了高内相共轭亚油酸(CLA)的水包油(O/W)乳液, 并通过热引发乳液聚合反应得到共轭亚油酸低聚体(oligo-CLA); 将oligo-CLA用于自组装脂肪酸囊泡(FAV). 透射电子显微镜和动态激光光散射表征结果均表明, 在pH=8.6~13范围内得到了囊泡粒径为10~30 nm的FAV, 此结果对提高FAV的pH适应性具有理论意义. 自乳液聚合实验结果表明, 该高内相自乳化/热引发低聚反应策略可以使浓度高达75.3%(质量分数)的CLA完成无外加表面活性剂乳液聚合, 并使共轭双键总自交联率达到33%且控制oligo-CLA的平均聚合度约为6, 对规模化生产oligo-CLA及构筑FAV具有实用价值. 与CLA相比, oligo-CLA具有更好的低温溶解性, 由其自组装的FAV具有更好的环境适应性, 如耐酸性和抗钙皂能力, 而且显示出较好的钙响应囊泡体积膨胀率; 以极少量非离子表面活性剂Span 40或AEO2辅助oligo-CLA形成的杂化囊泡具有更宽的pH适应性. 因此, 所制备的FAV在药物释放体系、 日用化学产品、 家用洗涤剂和个人护理产品中具有更广阔的应用前景.

关键词: 共轭亚油酸, 低聚体, 脂肪酸囊泡, 囊泡稳定性, 自乳液聚合

Abstract:

High internal phase O/W emulsion of conjugated linoleic acids(CLA) was prepared by self-emulsifying technology, and oligomer of CLA(oligo-CLA) was obtained by thermal self-emulsion polymerization(SEP) of the above emulsion. Furthermore, fatty acid vesicles(FAV) self-assemble by the oligo-CLA showing 10—30 nm diameter at pH=8.6—13 that was revealed by both transmission electron microscopy and dynamic light scattering, which has theoretical significance for FAV stable at a broader pH range. The experimental results show that free-surfactant emulsion polymerization was completed in the high internal phase emulsion of 75.3%(mass fraction) CLA according to the unique self-emulsification/thermal oligomerization strategy, achieving 33% total self-crosslinking degree and the target oligo-CLA with an average polymerization degree of 6, which is instructive for scaling up oligo-CLA and FAV preparation. The oligo-CLA has better low temperature solubility in comparison with CLA itself, and the FAV self-assembling by it has stronger resistance to acidic and calcium conditions and shows calcium responsive size-tunable features. Moreover, the hybrid vesicles of oligo-CLA with a small amount of Span 40 or AEO2 additives show even broader pH windows for vesiculation. Therefore the FAV self-assembling by oligo-CLA should have a wider application prospect in drug delivery systems, daily chemical products, and household detergents and personal care products.

Key words: Conjugated linoleic acid, Oligomer, Fatty acid vesicle, Vesicle stability, Self-emulsion polymerization

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