高等学校化学学报

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量子点标记的生物实时动态示踪成像研究进展

王洋, 邓玉林, 庆宏, 谢海燕   

  1. 北京理工大学生命科学与技术学院, 北京 100081
  • 收稿日期:2007-12-03 修回日期:1900-01-01 出版日期:2008-04-10 发布日期:2008-04-10
  • 通讯作者: 谢海燕

Advance in Real-time and Dynamic Biotracking and Bioimaging Based on Quantum Dots

WANG Yang, DENG Yu-Lin, QING Hong, XIE Hai-Yan*   

  1. School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081, China
  • Received:2007-12-03 Revised:1900-01-01 Online:2008-04-10 Published:2008-04-10
  • Contact: XIE Hai-Yan

摘要: 量子点的荧光特性及其在生物标记和成像应用中的实现, 为生命体系的高灵敏原位、实时及动态成像研究提供了新的发展契机, 已成为当前生物检测和成像的最前沿研究领域之一. 本文综述了量子点光物理性质、量子点标记生物荧光探针制备及其在实时动态示踪成像应用中的研究进展.

关键词: 量子点, 探针, 实时, 动态, 成像

Abstract: New development opportunities for ultra-sensitive, in situ, real-time and dynamic imaging in life sciences are emerging with fluorescent semiconductor quantum dots(QDs), which are of unique fluorescence properties and have been successfully applied in biological labeling and imaging. Nowadays, QDs-based labeling and imaging is one of the most important frontiers in biodetection and bioimaging. In this paper, the related photophysical properties of quantum dots, recent advance in the preparation of QDs-based fluorescent bioprobes and their applications in real-time and dynamic tracking and imaging are reviewed.

Key words: Quantum dots, Probe, Real-time, Dynamics, Imaging

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