剥离-共组装法制备葫芦素插层类水滑石纳米杂化物

doi:10.7503/cjcu20140159

高等学校化学学报 ›› 2014, Vol. 35 ›› Issue (9): 1982.doi: 10.7503/cjcu20140159

剥离-共组装法制备葫芦素插层类水滑石纳米杂化物

王爽, 兀晓文, 李海平, 张人杰, 侯万国()

山东大学胶体与界面化学教育部重点实验室, 济南250100

收稿日期:2014-03-03 出版日期:2014-09-10 发布日期:2019-08-01
作者简介:联系人简介: 侯万国, 男, 博士, 教授, 主要从事胶体与界面化学的研究. E-mail: wghou@sdu.edu.cn
基金资助:
国家自然科学基金(批准号: 21173135, 21273135)和高等学校博士学科点专项科研基金(批准号: 20110131130008)

Synthesis of Cucurbitacin Intercalated Hydrotalcite-like Compound Nanohybrids via Delamination-coassembling Method^†

WANG Shuang, WU Xiaowen, LI Haiping, ZHANG Renjie, HOU Wanguo^*()

Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Shandong University, Jinan 250100, China

Received:2014-03-03 Online:2014-09-10 Published:2019-08-01
Contact: HOU Wanguo E-mail:wghou@sdu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21173135, 21273135) and the Specialized Research Fund for the Doctoral Program of Higher Education of China(No.20110131130008)

摘要/Abstract

摘要：

采用剥离-共组装法制备了电中性疏水药物葫芦素(CA)插层类水滑石(HTlc)纳米杂化物. 先用胆酸钠(Ch)包覆修饰葫芦素, 再与剥离的HTlc薄片共组装, 形成CA-Ch-HTlc纳米杂化物. 采用小角X射线散射、傅里叶变换红外吸收光谱、透射和扫描电子显微镜、 Zeta电位和元素分析等技术对样品进行了表征. 所制备纳米杂化物的载药量达到7.06%, 表明该方法可以实现电中性疏水药物在HTlc上的有效负载. 依据胆酸离子和葫芦素尺寸及纳米杂化物通道高度推测, 胆酸离子在HTlc层间为双层排列, 其长轴几乎垂直于HTlc层板; 葫芦素分子插入(或“溶入”)胆酸离子双层中. CA-Ch-HTlc纳米杂化物具有良好的药物缓释效果, 其药物释放过程符合准二级动力学方程.

关键词: 类水滑石, 葫芦素, 剥离-共组装法, 纳米杂化物, 缓释

Abstract:

A nanohybrid of cucurbitacin(CA), a charge-neutral and poorly water-soluble drug, intercalated hydrotalcite-like compounds(HTlc) was synthesized via a delamination-coassembling method. CA molecules were initially incorporated into the micelles of sodium cholate(Ch), and the resulting negatively charged CA-loaded micelles and the positively charged delaminated HTlc nanosheets were then coassembled together into the CA-Ch-HTlc nanohybrid. The so-obtained nanohybrid was characterized by small angle X-ray scattering, Fourier transform infrared, transmission and scanning electron microscopy, zeta potential and elemental analyses. The results showed that the loading of CA in the nanohybrid was 7.06%, indicating that this route could be used to achieve the effective intercalation of charge-neutral and poorly water-soluble drugs into the HTlc gallery. Based on the sizes of Ch and CA, and the gallery heights of the nanohybrid, a possible orientation of Ch anions and CA molecules in the HTlc gallery was proposed. The Ch anions are arranged as a slightly tilted bilayer with their long axis approximately perpendicular to the brucite-like layer, and the CA molecules are encapsulated in the bilayer as a consequence of the hydrophobic interactions. The in vitro release of CA from the nanohybrid was examined, and the results showed that the nanohybrid had a good drug controlled release performance and its drug release process obeyed pseudo-second order kinetics model.

Key words: Hydrotalcite-like compound, Cucurbitacin, Delamination-coassembling method, Nanohybrid, Release

中图分类号:

O648

TrendMD:

王爽, 兀晓文, 李海平, 张人杰, 侯万国. 剥离-共组装法制备葫芦素插层类水滑石纳米杂化物. 高等学校化学学报, 2014, 35(9): 1982.

WANG Shuang, WU Xiaowen, LI Haiping, ZHANG Renjie, HOU Wanguo. Synthesis of Cucurbitacin Intercalated Hydrotalcite-like Compound Nanohybrids via Delamination-coassembling Method^†. Chem. J. Chinese Universities, 2014, 35(9): 1982.

图/表 7

Fig.1 Molecular structures of cucurbitacin B(A) and cucurbitacin E(B)

Fig.2 SAXS patterns of Zn2Al-NO3 HTlc(a), cucurbitacin(b), Ch-HTlc(c) and CA-Ch-HTlc(d)

Fig.3 Schematic illustration of CA-Ch-HTlc nanohybrid structure

Fig.4 FTIR spectra of HTlc(a), sodium cholate(b),Ch-HTlc(c), CA-Ch-HTlc(d) and cucurbitacin(e)

Fig.5 TEM(A, C) and SEM(B, D) images of HTlc(A, B) and CA-Ch-HTlc nanohybrid(C, D) Inset in image (A) is TEM image of delaminated HTlc nanosheets.

Fig.6 Release profiles of cucurbitacin from the physical mixture of Ch-HTlc and cucurbitacin(a) and CA-Ch-HTlc nanohybrids(b) (37 ℃, pH=7.4)

Fig.7 Pseudo-second order kinetics plots of cucurbitacin release from CA-Ch-HTlc nanohybrids

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剥离-共组装法制备葫芦素插层类水滑石纳米杂化物

Synthesis of Cucurbitacin Intercalated Hydrotalcite-like Compound Nanohybrids via Delamination-coassembling Method^†

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剥离-共组装法制备葫芦素插层类水滑石纳米杂化物

Synthesis of Cucurbitacin Intercalated Hydrotalcite-like Compound Nanohybrids via Delamination-coassembling Method†

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Synthesis of Cucurbitacin Intercalated Hydrotalcite-like Compound Nanohybrids via Delamination-coassembling Method^†