高等学校化学学报 ›› 2015, Vol. 36 ›› Issue (10): 1933.doi: 10.7503/cjcu20150353

• 物理化学 • 上一篇    下一篇

(羟基喜树碱@胆酸钠)-层状双金属氢氧化物纳米杂化物的组装及表征

庞秀江1(), 刘源1, 陈利2, 全贞兰1   

  1. 1. 青岛科技大学化学与分子工程学院, 生态化工国家重点实验室培育基地, 青岛 266042
    2. 高分子科学与工程学院, 橡塑材料与工程教育部重点实验室, 青岛 266042
  • 收稿日期:2015-04-30 出版日期:2015-10-10 发布日期:2015-09-14
  • 作者简介:联系人简介: 庞秀江, 女, 博士, 讲师, 主要从事微反应器制备超薄类水滑石纳米片及其应用研究. E-mail:xiujiangpang@qust.edu.cn
  • 基金资助:
    山东省自然科学基金联合专项(批准号: ZR2014BL005)和青岛科技大学博士基金(批准号: 0022610)资助

Fabrication and Characterization of (Hydroxyl camptothecin@sodium cholate)-layered Double Hydroxide Nanohybrids

PANG Xiujiang1,*(), LIU Yuan1, CHEN Li2, QUAN Zhenlan1   

  1. 1. State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering
    2. Key Laboratory of Rubber-Plastics, Ministry of Education/Shandong Provincial Key Laboratory of Rubber-plastics,College of Polymer Science and Engineering, Qingdao University of Science and Technology, Qingdao 266042, China
  • Received:2015-04-30 Online:2015-10-10 Published:2015-09-14
  • Contact: PANG Xiujiang E-mail:xiujiangpang@qust.edu.cn
  • Supported by:
    † Supported by the Natural Science Foundation of Shandong Province, China(No.ZR2014BL005) and the Doctoral Fund of Qingdao University of Science and Technology, China(No.0022610)

摘要:

采用“药物修饰-共组装”法制备了(羟基喜树碱@胆酸钠)-层状双金属氢氧化物纳米杂化物. 先用胆酸钠(SCL)包裹羟基喜树碱(HCPT)形成胶束, 再与微反应器制备的层状双氢氧化物(LDH)纳米片共组装形成纳米杂化物, 其载药量可达12.9%, 杂化物中HCPT以高生物活性的内酯形式存在. 采用聚乙二醇(PEG)和羧甲基纤维素(CMC)分别对所制备的(HCPT@SCL)-LDH纳米杂化物进行了表面修饰, 结果表明, 纳米杂化物的分散性得到明显改善; PEG的修饰效果优于CMC, 所获得的PEG-(HCPT@SCL)-LDH杂化物的平均粒径可小至约70 nm, 具有良好的分散性和药物缓释效果. 其药物释放过程可用准二级动力学方程描述, 颗粒内部扩散是药物释放过程的控制步骤.

关键词: 羟基喜树碱, 层状双金属氢氧化物, 共组装, 纳米杂化物

Abstract:

(Hydroxyl camptothecin@sodium cholate)-layered double hydroxide(LDH) nanohybrids were prepared by a modified drug-coassembly method. Firstly, Hydroxyl camptothecin(HCPT) was incorporated into micelles derived from sodium cholate(SCL) which negatively charged. The negatively charged micelles intercalated HCPT@SCL-LDH nanohybrids were prepared by a co-assembly between LDH nanosheets and sodium cholate micelles with the encapsulated HCPT could keep the biological active lactone form, and the drug loading of so-obtained nanohybrid was 12.9%.(HCPT@SCL)-LDH was modified using polyethylene glycol(PEG) and carboxymethylcellulose(CMC), respectively. The results showed that the dispersity of nanohybrids was obviously improved, and PEG worked better than CMC. The PEG-(HCPT@SCL)-LDH had favorable dispersity with average size of ca. 70 nm. PEG-(HCPT@SCL)-LDH showed well controlled release property and in vitro drug release kine-tics from the nanohybrids could be fitted with the pseudo-second-order kinetic model. The diffusion of HCPT through the LDH particles played an important role in controlling the drug release.

Key words: Hydroxyl camptothecin, Layered double hydroxide, Coassemble, Nanohybrid

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