高等学校化学学报 ›› 2011, Vol. 32 ›› Issue (7): 1478.

• 研究论文 • 上一篇    下一篇

富含羧基的球形介孔分子筛SBA-15的合成及药物释放性能

聂鑫1, 曲凤玉1,2, 李晓丰1, 林惠明1,2   

  1. 1.  哈尔滨师范大学化学化工学院,  
    2. 功能材料设计合成与绿色催化黑龙江省高校重点实验室,  哈尔滨  150025
  • 收稿日期:2010-09-19 修回日期:2011-04-27 出版日期:2011-07-10 发布日期:2011-06-02
  • 通讯作者: 曲凤玉 E-mail:qufengyu2010@yahoo.cn
  • 基金资助:

    国家自然科学基金(批准号:20871037)资助.

Synthesis of Spherical Mesoporous SBA-15  with Abundant Carboxyl and Drug Release Profile

NIE Xin1, QU  Feng-Yu1,2*, LI Xiao-Feng1, LIN Hui-Ming1,2   

  1. 1. College of Chemistry and Chemical Engineering,
    2. Key Laboratory of Design and Synthesis of Functional Materials and Green Catalysis, Colleges of Heilongjiang Province, Harbin Normal University, Harbin 150025, China
  • Received:2010-09-19 Revised:2011-04-27 Online:2011-07-10 Published:2011-06-02
  • Contact: QU Feng-Yu E-mail:qufengyu2010@yahoo.cn
  • Supported by:

    国家自然科学基金(批准号:20871037)资助.

摘要: 本文采用原位合成法合成了富含羧基的SBA-15球形介孔分子筛. 研究了修饰剂(三烷氧基氰乙基硅烷 CTES)的用量对介孔分子筛SBA-15形貌、孔径及BET比表面积的影响. 用粉末X射线衍射(XRD)、扫描电镜(SEM)、红外(IR)和氮气吸附/脱附对样品进行了详细的表征. 该材料展示了尺寸在0.5-1 μm规则的球形形貌、有序的二维六方相介孔结构、较大的比表面积和孔容、并且随着修饰剂用量的增加, SBA-15的孔径变小, 比表面积下降. 药物组装及缓释性能测试表明, 该材料具有较好的药物组装及缓释释放性能. 该材料在催化、药物载体和色谱分析填料等领域将具有潜在的应用.

关键词: 羧基修饰, SBA-15, 原位合成, 球形, 药物缓释

Abstract: Mesoporous SBA-15 spheres with abundant carboxyl were synthesized dy a one-step method. The effect of CTES on the morphologies, pore sizes and BET surface areas of mesoporous SBA-15 have been investigated. The samples were characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), nitrogen adsorption/desorption and infrared (IR). The morphologies of as-obtained products are sphere-like shapes. The materials possess highly ordered hexagonal mesoporous structure, and large specific surface area and pore volume, and the pore sizes range from 0.5 to 1 μm. The results show the pore size and the surface area of the materials decrease with the increase of modified dosage, obviously. The assembly and delivery test shows that the material has good assembly and drug delivery profiles. As-synthesized products have potential applications in catalysis, drug delivery and fillings for chromatography analysis.

Key words: carboxyl modified, SBA-15, one-step synthesized, spherical, drug release

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