高等学校化学学报 ›› 2011, Vol. 32 ›› Issue (5): 1194.

• 研究论文 • 上一篇    下一篇

可降解光交联聚酸酐与聚酰胺-甲基丙烯酰胺凝胶的合成及药物控释

陈阳娟,钟世安,师琼   

  1. 中南大学化学化工学院, 长沙 410083
  • 收稿日期:2010-08-05 修回日期:2010-09-27 出版日期:2011-05-10 发布日期:2011-04-11
  • 通讯作者: 钟世安 E-mail:zhongshian@yahoo.com.cn
  • 基金资助:

    湖南省自然科学基金(批准号: 06JJ4117)资助.

Synthesis of Degradable Poly(polyamidoamine-methacrylamide-g-anhydride) Photocrosslinked Gels and Their Controlled Drug Release Behavior

CHEN Yang-Juan, ZHONG Shi-An*, SHI Qiong   

  1. College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
  • Received:2010-08-05 Revised:2010-09-27 Online:2011-05-10 Published:2011-04-11
  • Contact: ZHONG Shi-An E-mail:zhongshian@yahoo.com.cn
  • Supported by:

    湖南省自然科学基金(批准号: 06JJ4117)资助.

摘要: 合成聚酰胺-胺型树状分子(PAMAM)并进行端基甲基丙烯酰基修饰,将最外层接枝光化学活性双键,修饰产物与甲基丙烯酸酐化癸二酸(MSA)用DMSO溶解并在光引发剂存在下,经过紫外光照射得到具有一定生物相容性的凝胶。运用1H NMR和FT-IR对聚酰胺-甲基丙烯酰胺的结构进行表征。凝胶的降解实验表明,聚酸酐含量为50-60wt%的凝胶以表面溶蚀的方式降解,随着甲基丙烯酸酐化癸二酸(MSA)在凝胶中含量不同,降解时间在45~60天之间,pH在6.5-8.06范围内改变。包埋氧氟沙星凝胶的降解实验表明,可以通过改变聚酸酐的含量控制降解时间和药物释放量。

关键词: 聚酰胺-甲基丙烯酰胺, 聚酸酐, 光交联, 表面溶蚀, 药物控释

Abstract: Polyamidoamine(PAMAM) dendrimers were methacylated by Methacryloyl chloride and photopolymerized with Methacrylated Sebacic Anhydride(MSA) to obtain degradable gels.Structures of the polymers were characterized by FT-IR and1H NMR. In order to study the effects of polyamidoamine double bond (PAMAM-DB):MSA ratio on the polymer degradation behavior, local pH, water uptake, mass loss and surface morphology in the course of degradation were explored.It is found that the gels containing 50-60wt% anhydride were good surface erosion materials. Degradation time and pH of degradable medium range from 45 to 60 days, and from 6.5 to 8.06, respectively.Sample with 50wt% anhydride was choosed as the bead of ofloxacin based on the degradation experiment.The result shows the drug-released time and content of drug could be controlled by varing the mass fraction of MSA.

Key words: Polyamidoamine-methacrylamide, Anhydride, Photocrosslink, Surface erosion, Controlled drug release.

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