高等学校化学学报 ›› 2014, Vol. 35 ›› Issue (5): 903.doi: 10.7503/cjcu20130849

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肿瘤靶向性高分子纳米载体研究现状与展望

于海洋1,3, 汤朝晖1, 宋万通1, 邓明虓2, 陈学思1()   

  1. 1.中国科学院长春应用化学研究所, 生态环境高分子材料重点实验室, 长春 130022
    2. 东北师范大学化学学院, 长春 130024
    3. 中国科学院大学, 北京 100049
  • 收稿日期:2013-09-02 出版日期:2014-05-10 发布日期:2014-04-17
  • 作者简介:联系人简介: 陈学思, 男, 博士, 研究员, 博士生导师, 主要从事生物可降解高分子研究. E-mail:xschen@ciac.ac.cn
  • 基金资助:
    国家自然科学基金(批准号: 51173184, 51233004, 51321062, 21074018, 51373168, 51390484, 51021003)和科技部国际合作专项(批准号: 2011DFR51090)资助

Current Status and Future Prospects of Polymeric Nanocarrier for Tumor Targeting

YU Haiyang1,3, TANG Zhaohui1, SONG Wantong1, DENG Mingxiao2, CHEN Xuesi1,*()   

  1. 1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences,Key Laboratory of Polymer Ecomaterials, Changchun 130022, China
    2. Faculty of Chemistry, Northeast Normal University, Changchun 130024, China
    3. University of Chinese Academy of Sciences, Beijing 100049, China
  • Received:2013-09-02 Online:2014-05-10 Published:2014-04-17
  • Contact: CHEN Xuesi E-mail:xschen@ciac.ac.cn
  • Supported by:
    † Supported by National Natural Science Foundation of China(Nos.51173184, 51233004, 51021003, 51321062, 21074018, 51373168, 51390484, 51021003) and Ministry of Science and Technology of China(International Cooperation and Communication Program)(No.2011DFR51090)

摘要:

综述了肿瘤靶向性高分子纳米载体在抗肿瘤药物的靶向性输送和控制释放方面的研究进展, 并详细介绍了被动肿瘤靶向性、 主动靶向性、 生物可降解性、 pH敏感性、 还原敏感性、 酶敏感性和温度敏感性高分子纳米载体的研究现状, 展望了该研究领域的发展方向.

关键词: 药物控释, 生物医用高分子, 生物可降解高分子, 抗肿瘤药物, 肿瘤靶向

Abstract:

This paper reviewed the progress of polymer nanocarriers for tumor targeting delivery and controlled release of anticancer drugs, and elaborated the researching status of polymer nano-carriers with passive tumor targeting, active targeting, biodegradability, pH-sensitivity, reductive sensitivity, enzyme sensitivity and temperature-sensitivity. Future direction of relative research was discussed.

Key words: Drugcontrolled release, Biomedical polymer, Biodegradable polymer, Anti-cancer drug, Tumor targeting

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