高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

聚L-乳酸/二氧化硅纳米复合材料及其表面诱导生成类骨磷灰石的制备

杨艳1, 颜世峰1, 李孝秀1, 尹静波1, 陈学思2   

    1. 上海大学高分子材料系, 上海 201800;
    2. 中国科学院长春应用化学研究所, 高分子物理与化学国家重点实验室, 长春 130022
  • 收稿日期:2008-06-17 修回日期:1900-01-01 出版日期:2008-11-10 发布日期:2008-11-10
  • 通讯作者: 尹静波,陈学思

Preparation of Poly(L-lactide)/Surface-Grafting Silica Nanocomposites and Their Surface Induction of Bone-like Apatite in Simulated Body Fluid

YANG Yan1, YAN Shi-Feng1, LI Xiao-Xiu1, YIN Jing-Bo1*, CHEN Xue-Si2*   

    1. Department of Polymer Materials, Shanghai University, Shanghai 201800, China;
    2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2008-06-17 Revised:1900-01-01 Online:2008-11-10 Published:2008-11-10
  • Contact: YIN Jing-Bo,CHEN Xue-Si

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摘要： 为改善纳米SiO2粒子在聚L-乳酸基体中的分散性, 将乳酸齐聚物接枝到纳米SiO2粒子表面, 通过IR, 29Si MAS NMR和TGA对改性SiO2进行表征. 以聚L-乳酸(PLLA)为基体, 加入乳酸齐聚物接枝改性的二氧化硅(g-SiO2)粒子, 采用溶液浇铸法制备PLLA/g-SiO2纳米复合材料, 测试其在模拟体液(SBF)中的生物活性. 通过XRD, IR, SEM和EDS表征手段, 考察材料表面类骨磷灰石形成能力. 结果表明, 乳酸齐聚物成功地接枝到SiO2表面, 当反应36 h时, g-SiO2接枝率最大(9.22%). 随着g-SiO2含量增加和浸泡时间的延长, 材料表面最初形成的无定形沉积物矿化成碳酸羟基磷灰石(Carbonated hydroxyapatite, CHA), 钙磷比为1.72, 类似于人骨无机质, 表明g-SiO2的引入能明显加速复合材料表面CHA沉积, 该复合材料有望成为骨修复填充材料和组织工程支架材料.

关键词: 模拟体液, 复合材料, 聚乳酸, 二氧化硅, 表面接枝, 类骨磷灰石

Abstract: In order to improve the dispersibility of nano-silica(SiO2) in the matrix of poly(L-lactide)(PLLA), the silica nanoparticles were surface-grafted with L-lactic acid oligomer. The surface-grafting reaction is confirmed via IR, 29Si MAS NMR and TGA analyses. The nanocomposites of surface-grafting silica(g-SiO2) with PLLA prepared through solvent-cast technique were immersed in simulated body fluid(SBF) to examine their bioactivity. Its apatite-forming ability was characterized by means of X-ray diffraction(XRD), Fourier transform infrared(FTIR) spectra, scanning electron microscopy(SEM) and energy-dispersive spectrometer(EDS). The results show that L-lactic acid oligomer can be successfully grafted onto silica surface. The highest grafting amounts of L-lactic acid are 9.22% when the reaction time is 36 h. With the increase of filler content and soaking time, the amorphous surface coating is transformed into carbonated hydroxyapatite(CHA), the molar ratio of Ca to P is about 1.72, close to that of apatite. This kind of nanocomposites could be one of the best potential bioactive materials for bones substitute or as a tissue engineering scaffold.

Key words: Simulated body fluid, Composite material, Polylactide, Silica, Surface grafting, Bone-like apatite

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