高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

Cecropin B抗菌肽接枝丝素蛋白膜的制备和表征

白利强1, 马廷方2, 姚菊明1   

    1. 浙江理工大学材料与纺织学院, 教育部先进纺织材料与制备技术重点实验室, 杭州310018;
    2. 万事利集团有限公司, 杭州310021
  • 收稿日期:2007-01-22 修回日期:1900-01-01 出版日期:2007-08-10 发布日期:2007-08-10
  • 通讯作者: 姚菊明

Preparation and Characterization on Cecropin B Peptide Grafted with Silk Fibroin Films

BAI Li-Qiang1, MA Ting-Fang2, YAO Ju-Ming1*   

    1. The Key Laboratory of Advanced Textile Materials and Manufacturing Technology of Ministry of Education, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, China;
    2. Wensli Group Co. Ltd., Hangzhou 310021, China
  • Received:2007-01-22 Revised:1900-01-01 Online:2007-08-10 Published:2007-08-10
  • Contact: YAO Ju-Ming

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摘要： 以体积分数为60%的乙醇处理制得不溶性再生丝素膜, 通过碳二亚胺法将Cecropin B抗菌肽共价接枝到丝素膜表面, 利用红外光谱、扫描电镜、X射线能谱和抗菌性测试等手段对制得的丝素膜结构和表面特性及其抗菌性能进行了测试分析. 结果表明, Cecropin B抗菌肽成功地接枝到了丝素膜的表面, 接枝后的丝素膜水溶性低, 并具有良好、 持久的抗菌能力.

关键词: 丝素膜, 抗菌肽, 表面改性, 抗菌材料

Abstract: The undisolvable Bombyx mori silk fibroin film was prepared from the regenerated silk fibroin solution followed with the 60%(volume fraction) ethanol aqueous solution treatment. The silk fibroin film was grafted with Cecropin B peptide via the carbodiimide chemistry. The secondary structure, the film surface properties and the bacteriostatic activity of the obtained silk fibroin film were analyzed with FTIR, SEM, EDS and the antibacterial tests. The results show that the Cecropin B peptide is covalently grafted onto the surface of silk fibroin film, which is undisolvable and has an effective and permanent bacteriostatic activity.

Key words: Silk fibroin film, Antibacterial peptide, Surface modification, Antibacterial material

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