高等学校化学学报

高等学校化学学报

• 研究简报 • 上一篇    下一篇

NMR确定手性α-羟基酮的绝对构型

杨春晖1; 陈静文1; 李勤1; 彭昆2; 潘鑫复2; 崔育新1,3   

  1. 1. 北京大学药学院, 天然药物及仿生药物国家重点实验室, 北京 100083;
    2. 兰州大学化学系, 应用有机化学国家重点实验室, 兰州 7300002; 3. 北京大学医药卫生分析中心, 北京 100083
  • 收稿日期:2005-07-25 修回日期:1900-01-01 出版日期:2006-07-10 发布日期:2006-07-10
  • 通讯作者: 崔育新

Determination of Absolute Configuration of α-Hydroxy Ketones Using NMR

YANG Chun-Hui1; CHEN Jing-Wen1; LI Qin1; PENG Kun2; PAN Xin-Fu2; CUI Yu-Xin1,3   

  1. 1. State Key Laboratory of Natural and Biomimetic Drugs, School of
    Pharmaceutical Sciences, Peking University, Beijing 100083, China;
    2. Department of Chemistry, State Key Laboratory of Applied Organic
    Chemistry, Lanzhou University, Lanzhou 730000, China;
    3. Medical and Healthy Analysis Center, Peking University, Beijing 100083,
    China
  • Received:2005-07-25 Revised:1900-01-01 Online:2006-07-10 Published:2006-07-10
  • Contact: CUI Yu-Xin

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被引次数

1

摘要： 本文采用该方法将α羟基酮分别与(R)和(S)-2-甲氧基-2-苯基-2-三氟甲基乙酸(MTPA)反应, 得到(S)和(R)-Mosher酯, 再分别测定其 1H NMR谱, 通过计算化学位移差值确定其绝对构型.

关键词: α-羟基酮, 绝对构型, Mosher方法, 核磁共振

Abstract: In this paper a simpler Mosher′s method was developed from the modified Mosher′s method. It only need one configuration of MTPA to determine the absolute configurations of four αhydroxy ketones with their(S)-and(R)-MTPA esters using 1H NMR. The signals of protons on the same side with phenyl ring will be in the higher field than those of on the different side ones.

Key words: α-Hydroxy ketones, Absolute configuration, Mosher′s method, NMR

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