高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (8): 1474.

• 研究快报 • 上一篇    下一篇

钯催化偶合卟吩-并合杂环顺烯二炔二联体的合成

殷军港1,2, 王进军2, 沈荣基3   

  1. 1. 兰州大学化学化工学院, 兰州730000;
    2. 烟台大学应用化学系, 烟台265005;
    3. 韩国仁济大学, 釜山
  • 收稿日期:2004-08-26 出版日期:2005-08-10 发布日期:2005-08-10
  • 通讯作者: 王进军(1955年出生),男,博士,教授,从事天然产物和杂环药物的合成研究.E-mail:wjj1955@163.com E-mail:wjj1955@163.com
  • 基金资助:

    国家科技部中韩政府间合作研究(2002)项目;山东省技术创新重点项目(批准号:200391006008)资助.

Synthesis of Chlorin-enediyne Dyads Fused with Heterocyclic Ring by Palladium-catalyzed Coupling Reaction

YIN Jun-Gang1,2, WANG Jin-Jun2, SHIM Young-Key3   

  1. 1. Collgeg of Chemistry and Chemical Engineering, Lanzhou 730000, China;
    2. Department of Applied Chemistry, Yantai University, Yantai 264005, China;
    3. School of Nano Engineering, Inji University, Pusan, Korea
  • Received:2004-08-26 Online:2005-08-10 Published:2005-08-10

PDF (PC)

被引次数

1

关键词: 偶联反应, 焦脱镁叶绿酸, 卟吩-顺烯二炔二联体, 光动力疗法

Abstract: The terminal alkyne was constructed in chlorin chromophore by Grignard reaction and oxidation to give chlorin 2 and 3, respectively. After deprotection the diketo chlorin 4 was obtained which was readily converted to the Zn-complex 5. Chlorin-enediyne dyads 6 fused with heterocyclic ring was synthesized by a palladium-catalyzed coupling reaction with 2-(1-hexynyl)-3-chlorothiophene.

Key words: Coupling reaction, Pyropheophorbide, Chlorin-enediyne dyads, Photodynamic therapy

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