高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (6): 1174.

• 研究快报 • 上一篇    下一篇

生物可降解5-氟尿嘧啶载药微球的制备及性能研究

尹静波1, 陈红丹1, 罗坤1, 庄秀丽2, 陈学思2, 曹田1   

  1. 1. 上海大学高分子材料系, 上海201800;
    2. 中国科学院长春应用化学研究所, 高分子物理与化学国家重点实验室, 长春130022
  • 收稿日期:2005-02-28 出版日期:2005-06-10 发布日期:2005-06-10
  • 通讯作者: 尹静波(1964年出生),女,博士,副教授,主要从事高分子载体催化剂和医用高分子研究.E-mail:jbyin@staff.shu.edu.cn E-mail:jbyin@staff.shu.edu.cn; xschen@ciac.jl.cn
  • 基金资助:

    国家自然科学基金(批准号:50473061)资助.

Preparation and Properties of Biodegradable Microspheres Containing 5-Fluorouracil

YIN Jing-Bo1, CHEN Hong-Dan1, LUO Kun1, ZHUANG Xiu-Li2, CHEN Xue-Si2, CAO Tian1   

  1. 1. Department of Polymer Materials, Shanghai University, Shanghai 201800, China;
    2. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2005-02-28 Online:2005-06-10 Published:2005-06-10

PDF (PC)

被引次数

42

关键词: 5-氟尿嘧啶, 聚乳酸(PLA), 乳酸-乙二醇(PLA-PEG), 微球, 纳米二氧化硅, 控制药物释放

Abstract: Microspheres containing an antimetabolite drug 5-Fluorouracil were prepared from (poly(lactic) acide)(PLA) or poly(lactic acid)-polyethylene glycol(PLA-PEG) as the carrier by using a water-in-oil-in-water emulsion solvent evaporation technique. The conditions of the microspheres preparation such as polymer concentration in organic solvent, relative molecular weight of PLA-PEG and PLA/PEG mass ratio were discussed. The surface morphology and the size of the microspheres were observed by SEM. The drug content of microspheres was examined by TGA and the drug release in vitro was evaluated. According to the results, the drug content increased with the nano-silica used. The highest drug content in this study was 39.9%. The drug-release kinetics satisfied the requirements of controlled drug-release.

Key words: 5-Fluorouracil, Poly(lactic acide)(PLA), Poly(lactic acid)-polyethylene glycol(PLA-PEG), Microspheres, Nano-silica, Controlled drug-release

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