高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (11): 2066.

• 研究快报 • 上一篇    下一篇

慢性肾衰患者血清中分子物质浓度变化及其对Na,K-ATP酶的抑制作用

杨眉1, 储结根1, 张建达1, 袁直1, 杨洪涛2, 刘宏富3, 赵菁丽2, 杨淑芬3   

  1. 1. 南开大学高分子化学研究所,天津300071;
    2. 天津市中医学院第一附属医院,天津300193;
    3. 天津市天和医院,天津300050
  • 收稿日期:2004-10-10 出版日期:2005-11-10 发布日期:2005-11-10
  • 基金资助:

    国家“九七三”计划项目(批准号:G1999064707)资助

Concentration Variation of Middle Molecules in Sera of Chronic Renal Failure Patients and Inhibition for Na,K-ATPase

YANG Mei1, CHU Jie-Gen1, ZHANG Jian-Da1, YUAN Zhi1, YANG Hong-Tao2, LIU Hong-Fu3, ZHAO Jing-Li2, YANG Shu-Fen3   

  1. 1. Institute of Polymer Chemistry,Nankai University,Tianjin 300071,China;
    2. First Teaching Hospital,Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China;
    3. Tianhe Hospital,Tianjin 300050,China
  • Received:2004-10-10 Online:2005-11-10 Published:2005-11-10

关键词: 慢性肾衰, 中分子, Na, K-ATP酶

Abstract: Sera from patients with different courses of chronic renal failure and healthy persons were separated by gel permeation chromatography,and the concentration of middle molecular fraction B were calculated.The concentration of fractions B was increasing with the aggravating of renal failure degree,which indicated that the concentration of fraction B was related to patient's renal failure.Fractions B from uremic urine,uremic sera or normal urine were resolved into 10 to 17 sub-fractions by ion exchange chromatography.Sub-fractions from normal urine and from uremic sera were assayed for their inhibition for the activity of Na,K-ATPase.The results showed that the Na,K-ATPase activities of the samples with B-8 and B-9 were much lower than that of blank.It is indicated that B-8 and B-9 contained some compounds which could inhibit the activity of Na,K-ATPase.

Key words: Chronic renal failure, Middle molecule, Na,K-ATPase

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