高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (10): 1963-1965.

• 研究简报 • 上一篇    下一篇

层层静电自组装构建壳聚糖/肝素抗菌多层膜的研究

袁伟永, 计剑, 付金红, 沈家骢   

  1. 浙江大学高分子科学与工程系, 杭州310027
  • 收稿日期:2004-11-26 出版日期:2005-10-10 发布日期:2005-10-10
  • 基金资助:

    国家高技术研究发展计划“八六三”计划项目(批准号:2001AA326030)资助

Construction of Anti-bacterial Multilayer Films via Layer-by-layer Electro Static Self-assembly of Chitosan and Heparin

YUAN Wei-Yong, JI Jian, FU Jin-Hong, SHEN Jia-Cong   

  1. Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China
  • Received:2004-11-26 Online:2005-10-10 Published:2005-10-10

关键词: 抗菌涂层, 层层自组装, 聚酯, 表面修饰

Abstract: Chitosan as an antibacterial agent and heparin as an anti-adhesive agent were alternatively deposited onto aminolyzed poly(ethylene terephthalate)(PET) to construct anti-adhesive and antibacterial multilayer films.The contact angle and UV data verified the progressive build-up of the multilayer film by alternate deposition of the polyelectrolytes.PRT experiment and in vitro antibacterial assay indicated that the multilayer-modified PET films had much better hemocompatibility and much stronger antibacterial performance than(unmodified) PET.Such an easy processing and shape-independent method to prepare an anti-adhesive and(antibacterial) surface may have a good potential for surface modification of cardiovascular devices.

Key words: Antibacterial multilayer films, Layer-by-layer self-assembly, Polyester, Surface modification

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