高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (10): 1941-1945.

• 研究论文 • 上一篇    下一篇

两亲性超支化聚砜胺对染料的可逆高装载

刘翠华, 高超, 曾浩, 颜德岳   

  1. 上海交通大学化学化工学院, 上海200240
  • 收稿日期:2004-12-10 出版日期:2005-10-10 发布日期:2005-10-10
  • 基金资助:

    国家自然科学基金(批准号:20304007,50233030);霍英东教育基金(批准号:91013);上海市启明星计划基金(批准号:03QB14028)资助

Reversible and High Dye-Loading of Amphiphilic Hyperbranched Poly(sulfone-amine)s

LIU Cui-Hua, GAO Chao, ZENG Hao, YAN De-Yue   

  1. College of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China
  • Received:2004-12-10 Online:2005-10-10 Published:2005-10-10

摘要: 采用戊酰氯、壬酰氯和棕榈酰氯对超支化聚砜胺(HPSA)进行封端,合成了3种不同烷基末端的两亲性核壳型超支化聚砜胺,并将其用于小分子装载.发现它们对刚果红(CR)、甲基橙(MO)、虎红(RB)等水溶性染料具有很强的装载能力,且对同种染料的封装载荷随着末端亲油性烷基链的增长而增大.对于末端为棕榈酰基的HPSA-PC,平均每个大分子可以捕捉CR和MO分子的数目分别高达41.8和19.4个,远高于已报道的树枝状聚合物和超支化聚合物对这些染料的封装载荷.这主要是聚砜胺内核的高度亲水性及其与亲油性烷基外壳的极性差所致.与已报道的聚合物不同,两亲性超支化聚砜胺装载的染料用纯水洗涤可以释放出来.这种高装载性能和可逆性赋予超支化聚砜胺在药物释放、分子识别和分离以及纳米催化剂和纳米涂料等领域具有广阔的应用前景.

关键词: 超支化聚砜胺, 两亲性, 装载, 染料, 可逆

Abstract: Three samples of core-shell amphiphilic hyperbranched poly(sulfone-amine)(HPSA) were synthesized by end-capping of hyperbranched poly(sulfone-amine) with valeryl chloride,nonanoyl chloride and palmitoyl chloride in the presence of triethylamine.They exhibit high capabilities to load water soluble dyes,such as congo red(CR),methyl orange(MO) and rose bengal(RB).It is found that the longer the terminal hydrophobic chain is,the higher the loading capability would be for the same dye.The maximum loading quantity of our hyperbranched macromolecular vessel is an order of magnitude higher than that of dendritic box for MO,and is 1—2 orders of magnitude higher than that of other hyperbranched polymers reported before for CR.For the palmitoyl-terminated HPSA,the average number of dye molecules trapped by per macromolecule achieves 41.8 of CR,19.4 of MO,and 3.0 of RB,respectively.Such high loading-capability is considered to attribute to the high water-solubility of the hyperbranched poly(sulfone-amine) core and the large polarity difference between the hydrophilic core and hydrophobic shell.Interestingly,the loaded dyes can be released from the molecular vessel by mixing its chloroform solution with pure water.The high loading capability associated with the reversible releasing property would pave the way for the molecular vessels in the application of drug transfer/delivery,selective molecular recognition and separation,nanocatalysis and nanocoating.

Key words: Hyperbranched poly(sulfone-amine)s, Amphiphilicity, Load, Dye, Reversiblity

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