高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (1): 188.

• 研究简报 • 上一篇    下一篇

磷酸胆碱基细胞膜仿生药物缓释涂层材料的研究

徐建平1, 计剑1, 陈伟东1, 范德增2, 孙福玉2, 沈家骢1   

  1. 1. 浙江大学高分子科学与工程学系, 杭州 310027;
    2. 安泰科技股份有限公司, 北京 100081
  • 收稿日期:2003-02-18 出版日期:2004-01-24 发布日期:2004-01-24
  • 通讯作者: 计 剑(1969年出生),男,博士,副教授,主要从事生物医用高分子、血液相容性材料、介入医用材料和组织工程材料的研究.E-mail:Jianji@mail.hz.zj.cn E-mail:Jianji@mail.hz.zj.cn
  • 基金资助:

    国家高技术研究发展计划“八六三”项目(批准号:2001AA326030)资助

A Bioinspired Phospholipid Polymer as Drug-laden Coating for Biomedical Device

XU Jian-Ping1, JI Jian1, CHEN Wei-Dong1, FAN De-Zeng2, SUN Fu-Yu2, SHEN Jia-Cong1   

  1. 1. Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China;
    2. Advanced Technology & Materials Corp., Beijing 100081, China
  • Received:2003-02-18 Online:2004-01-24 Published:2004-01-24

关键词: 生物相容性, 磷酸胆碱, 药物缓释, 生物模拟

Abstract: A novel bioinspired phospholipid copolymer was synthesized by the free radical polymerization of poly-2-methacryloyloxyethylphosphorylcholine(MPC), stearyl methacrylate(SMA), hydroxypropyl methacrylate(HPMA) and trimethoxysilylpropyl methacrylate(TSMA). A stable cross-linked coating was obtained via dip-coating, followed by curing at 70 ℃ for 9 h. Contact angle results indicate the coating surface rearrange to get a more hydrophilic surface on the polymer/water interface. The membrane mimic phosphorylcholine coating surface can resist the platelet adhesion and prolong plasma recalcification time significantly. Rhodamine S was used as model drugs to prepare drug-containing coating under the same conditions. Drug-releasing curves fall into Fickian release mechanism and there exists an efficient releasing-amount of the drug until 60 h.

Key words: Biocompatibility, Phosphorylcholine, Drug-delivering, Biomimetism

中图分类号: 

TrendMD: