高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (7): 1231.

• 研究简报 • 上一篇    下一篇

功能化基团对C60-β-丙氨酸衍生物清除超氧阴离子自由基O2-·能力的影响

孙涛, 徐铸德, 贾之慎   

  1. 浙江大学化学系, 玉泉校区, 杭州 310027
  • 收稿日期:2002-01-12 出版日期:2003-07-24 发布日期:2003-07-24
  • 通讯作者: 徐铸德(1944年出生),男,教授,博士生导师,从事化学动力学和功能分子材料研究.E-mail:pchem@zju.edu.cn E-mail:pchem@zju.edu.cn
  • 基金资助:

    国家教育部博士点基金(批准号:97033510);国家自然科学基金(批准号:20171039)资助

Effect of Functional Groups on the Activity of Water-soluble β-Alanine C60Derivatives for Superoxide Anion Radical Scavenging

SUN Tao, XU Zhu-De, JIA Zhi-Shen   

  1. Department of Chemistry, Yuquan Campus, Zhejiang University, Hangzhou 310027, China
  • Received:2002-01-12 Online:2003-07-24 Published:2003-07-24

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关键词: C60-&beta, 丙氨酸衍生物, 超氧阴离子自由基O2-·, , 邻苯三酚自氧化, 化学发光

Abstract: Three water-soluble β-alanine C60 adducts with different addition numbers, C60(NHCH2CH2COONa) nH n(n=1,5,9), were synthesized. The products were characterized by FTIR, 1HNMR and elemental analysis. The antioxidant activity of these C60 adducts as the quencher for superoxide anion radical O2-· was evaluated by chemiluminescence in the system of pyrogallol-luminol. The results indicate that the three C60 derivatives are all excellent quencher for superoxide anion radical O2-·. The concentrations of 50% inhibition are 252, 140, 112 μmol/L respectively. This high efficiency should be attributed to many factors such as the numbers of remaining double bonds, donor effect of amino group and steric effect. However, the above results also suggest the effect of the adducted β-alanine groups is predominated in this system.

Key words: β-Alanine C60 derivatives, Superoxide anion radical O2-·, Auto-oxidation of pyrogallol, Chemiluminescence

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