高等学校化学学报

高等学校化学学报 ›› 2003, Vol. 24 ›› Issue (11): 1997.

• 论文 • 上一篇    下一篇

(+)-O-萘基环状磷酰二胺酯的合成、晶体结构及绝对构型

何可1, 周正洪1, 赵国锋1, 王宏根2, 唐除痴1   

  1. 1. 南开大学元素有机化学国家重点实验室, 元素有机化学研究所;
    2. 南开大学中心实验室, 天津 300071
  • 收稿日期:2002-10-15 出版日期:2003-11-24 发布日期:2003-11-24
  • 通讯作者: 唐除痴(1938年出生),男,教授,博士生导师,从事有机化学研究.E-mail:c.c.tang@eyou.com E-mail:c.c.tang@eyou.com
  • 基金资助:

    国家自然科学基金(批准号:20272025);教育部博士学科点基金资助

Synthesis, Crystal Structure and Absolute Configuration of (+)-O-Naphthyl Cyclophosphorodiamidate

HE Ke1, ZHOU Zheng-Hong1, ZHAO Guo-Feng1, WANG Hong-Gen2, TANG Chu-Chi1   

  1. 1. State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University;
    2. Central Laboratory, Nankai University, Tianjin 300071, China
  • Received:2002-10-15 Online:2003-11-24 Published:2003-11-24

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被引次数

2

摘要： 合成了目标化合物(+)-O-萘基环状磷酰二胺酯,其结构由1HNMR,31PNMR及元素分析确定,并在273K下进行了X射线衍射晶体结构分析.该化合物晶体属正交晶系,P212121空间群,晶胞参数a=1.0028(4)nm,b=1.1406(4)nm,c=2.4455(8)nm,V=2.7971(18)nm3,Z=4,Dc=1.212g/cm3,F(000)=1088,μ=0.129mm-1.晶体的结构收敛最终偏离因子R和wR分别为0.0585和0.0827.Flackx参数为0.03(12).目标化合物中磷原子的绝对构型为S.

关键词: O-萘基环状磷酰二胺酯, 晶体结构, 绝对构型

Abstract: The title compound(+)-O-naphthyl cyclophosphorodiamidate(C32H35N2O2P, Mr=510.59) has been synthesized and characterized by 31PNMR, 1HNMR and elemental analysis.X-ray diffraction analysis at 273(2) Kindicates that the compound belongs to orthorhombic system, space group P212121with cell parameters: a=1.0028(4) nm, b=1.1406(4) nm, c=2.4455(8) nm, V= 2.7971(18) nm3, Z=4, Dc=1.212 g/cm3, F(000)=1088, μ=0.129 mm-1. The structure parameters were refined by full-matrix least-squares on F2to R=0.0585 and wR=0.0827. The flack x pamameter was 0.03(12).The absolute configuration of the phosphoruSIn the title compound is S.

Key words: O-Naphthyl cyclophosphorodiamidate, Crystal structure, Absolute configuration

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