高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (4): 570.

• 研究简报 • 上一篇    下一篇

温度限制串联相关神经网络及其在细菌辨识中的应用

张卓勇1, Aaron Urbas2, Peter de B Harrington2, Kent J. Voorhees3, Jon Rees3   

  1. 1. 首都师范大学化学系, 北京100037;
    2. 俄亥俄大学化学系, Athens 45701-2979, 美国;
    3. 科罗拉多矿学院地球化学系, Golden, CO80401, 美国
  • 收稿日期:2001-01-05 出版日期:2002-04-24 发布日期:2002-04-24
  • 通讯作者: 张卓勇(1956年出生),男,博士,教授,博士生导师,从事光谱分析及化学计量学研究.
  • 基金资助:

    教育部中青年骨干教师基金资助.

Temperature-constrained Cascade Correlation Network andIts Application to Bacteria Identification

ZHANG Zhuo-Yong1, Aaron Urbas2, Peter de B Harrington2, Kent J. Voorhees3, Jon Rees3   

  1. 1. Department of Chemistry, Capital Normal University, Beijing 100037, China;
    2. Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701-2979, USA;
    3. Department of Geochemistry, Colorado School of Mines, Golden, CO 80401, USA
  • Received:2001-01-05 Online:2002-04-24 Published:2002-04-24

关键词: 细菌, MALDI, 飞行时间质谱, TCCCN, 人工神经网络

Abstract: The theoretical basis of temperature constrained cascade correlation network(TCCCN) was in-troduced briefly.The TCCCNmodels were used to identify various bacteria from their matrix-assistedlaser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF-MS) data.The identificationof eight different bacteria and the bacteria identification based on different culture time have been dis-cussed.The results show that the TCCCNcould produce robust and feature-oriented models for bacteria i-dentification based on MALDI-TOF-MS.However, mis-identification may occur for some bacteria sam-ples due to variation in cell biology under environmental conditions.

Key words: Bacteria, MALDI, Time-of-flight mass spectrometry, TCCCN, Artificial neural network

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