高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (8): 1205.

• 研究快报 • 上一篇    下一篇

用左旋多巴-示差脉冲伏安法间接测定生物样品中的铝

章福平, 毕树平, 刘锋, 卞宁生   

  1. 南京大学化学系, 配位化学国家重点实验室, 南京 210093
  • 收稿日期:2000-01-26 出版日期:2000-08-24 发布日期:2000-08-24
  • 通讯作者: 毕树平(1961年出生),男,博士,教授,博士生导师,主要从事电分析和环境分析化学研究.
  • 基金资助:

    国家自然科学基金(批准号:49831005,29777013);中国科学院长春应用化学研究所电化学开放实验室开放基金资助

Indirect Differential Pulse Voltammetric Determination of Aluminum in Biological Samples with L-Dopa

ZHANG Fu-Ping, BI Shu-Ping, LIU Feng, BIAN Ning-Sheng   

  1. Department of Chemistry, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China
  • Received:2000-01-26 Online:2000-08-24 Published:2000-08-24

关键词: 左旋多巴, 铝, 示差脉冲伏安法

Abstract: Electroanalytic direct determination of aluminum is a difficult subject because of the highly negative reductive potential of Al(Ⅲ) and interference of H+. But developing methods for the determination of trace amount of aluminum in environmental and biological samples is a hot topic in recent decades owning to the recognition of the potential toxic effects of aluminum. In this paper, the indirect differential pulse voltammetric(DPV) determination of aluminum with L-dopa(3,4-dihydroxyphenylalanine) on glass carbon working electrode has been reported. This novel method bases on the linear decrease of DPVanodic peak current of Ldopa with the concentration of aluminum added. Under the optimum experimental conditions (pH8.5, 0.08 mol/Lbuffer solution, 4×10-4 mol/L Ldopa), the linear range and the detection limit are (2—18)×10-7 and 7.6×10-8 mol/L Al(Ⅲ) respectively, the relative standard deviation for 2×10-5 mol/L Al (Ⅲ) is 2.4%(n=10). Anumber of foreign species, especially those necessary components in human body such as ascorbic acid, citrate, phosphate, Fe(Ⅲ), Fe(Ⅱ), Cu(Ⅱ), Zn(Ⅱ), Ca(Ⅱ) and Mg(Ⅱ) for interference have been studied. Satisfactory recoveries have been obtained by applying this method to determining aluminum in biological samples including mineral water, synthetic renal dialysate, urine and hair. The significance of the method and solutions to possible interference encountered in in vivo detection are discussed. Anew direction for further development of the in vivo determination of aluminum is provided in this studies.

Key words: L-Dopa(3,4-dihydroxyphenylalanine), Aluminum, Differential pulse voltammetry

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