高等学校化学学报

高等学校化学学报 ›› 2000, Vol. 21 ›› Issue (1): 85.

• 研究简报 • 上一篇    下一篇

水分子对磺酰脲类分子构效关系影响的研究

马翼, 刘洁, 李正名   

  1. 南开大学元素有机化学国家重点实验室, 元素有机化学研究所, 天津 300071
  • 收稿日期:1999-02-04 出版日期:2000-01-24 发布日期:2000-01-24
  • 通讯作者: 李正名(1931年出生),男,硕士,教授,博士导师,主要从事农药化学研究.
  • 基金资助:

    国家自然科学基金(批准号:29772019)资助

The Influence of Water Molecules in the Structure-activity Relationship Study of Sulfonylurea Molecules

MA Yi, LIU Jie, LI Zheng-Ming   

  1. National Elemento-organic Chemistry Key Laboratory, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China
  • Received:1999-02-04 Online:2000-01-24 Published:2000-01-24

PDF (PC)

被引次数

6

关键词: 溶剂作用, 水, 磺酰脲, ALS酶, 结构与活性关系

Abstract: A study of some sulfonylurea molecules with consideration of water molecules as its solvent was undertaken. The influence of the water molecules on the structure-activity relationship of the 35 sulfonylurea molecules was discussed . By supper-imposition of structural sulfonyl molecules, a molecular RMS was correlated with pI50, which denotes that the configuration difference in water solution is one of the reasons which causes the difference in bioactivity.

Key words: Solvent, Water, Sulfonylurea, ALS enzyme, Structure-activity relationship

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