高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (5): 709.

• 论文 • 上一篇    下一篇

中性红作为DNA作用方式光谱探针的研究

曹瑛, 李一峻, 何锡文   

  1. 南开大学化学系, 天津 300071
  • 出版日期:1999-05-24 发布日期:1999-05-24
  • 通讯作者: 何锡文
  • 作者简介:曹 瑛,女,28岁,博士.
  • 基金资助:

    国家自然科学基金(批准号:29575200);教育部博士点基金

Studies on an Immunosensor of Albumin Based on Surface Plasmon Resonance

CAO Ying, LI Yi-Jun, HE Xi-Wen   

  1. Department of Chemistry, Nankai University, Tianjin, 300071
  • Online:1999-05-24 Published:1999-05-24

摘要: 以溴乙锭(EB)为探针在研究吩噻嗪药物与DNA间相互作用的基础上,用中性红(NeutralRed,NR)代替EB为DNA作用方式对光谱探针的可行性进行了研究.结果表明,NR作为DNA作用方式光谱探针与EB具有可比性,且由于其低毒性和高稳定性而具有较好的应用潜力.

关键词: 中性红, 脱氧核糖核酸, 吩噻嗪药物, 光谱探针

Abstract: The possibilities of neutral red (NR) as DNA interacting mode spectroscopic probe instead of ethidium bromide (EB) is investigated in th is paper based on the studies of interaction of phenoth iozine drugs with DNA by EB probe. The result indicates that as DNA interacting mode probe, NR could match with EB. And with lower toxicity and higher stability than EB, NR has good potentialities to be used as interacting mode spectroscopic probe of DNA.

Key words: Neutral red, DNA, Phenoth iozine drugs, Spectroscopicprobe

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