高等学校化学学报 ›› 1999, Vol. 20 ›› Issue (10): 1559.

• 论文 • 上一篇    下一篇

3-芳胺甲烯基-6-烷基(芳基)-5,6-二氢-2H-吡喃-2,4-二酮的合成及其杀菌活性的研究

王有名, 李正名, 李佳凤, 李树正, 张素华   

  1. 南开大学元素有机化学研究所, 天津 300071
  • 收稿日期:1999-01-04 出版日期:1999-10-24 发布日期:1999-10-24
  • 通讯作者: 李正名
  • 作者简介:王有名,男,28岁,博士研究生.
  • 基金资助:

    国家自然科学重点基金(批准号:29832050)资助课题

Synthesis and Fungicidal Activity of 3-Anilinomethylene-5,6-dihydro-6-alkyl(aryl)-2H-pyran-2,4-diones

WANG You-Ming, LI Zheng-Ming, LI Jia-Feng, LI Shu-Zheng, ZHANG Su-Hua   

  1. Institute of Elemento Organic Chemistry, Nankai University, Tianjin 300071, China
  • Received:1999-01-04 Online:1999-10-24 Published:1999-10-24

摘要: 以5,6-二氢-6-烷基(芳基)-2H-吡喃-2,4-二酮(1)、芳胺(2)和原甲酸三乙酯进行缩合反应,合成了20个3-芳胺甲烯基-6-烷基(芳基)-5,6-二氢-2H-吡喃-2,4-二酮(3).由于分子内氢键的形成,化合物3由一对构象异构体4和5组成.生物活性初步测定结果表明,这些化合物均有一定的杀菌活性.

关键词: 缩合反应, 分子内氢键, 构象异构体, 杀菌活性

Abstract: 3-Anilinomethylene-6-alkyl(aryl)-5,6-dihydro-2H-pyran-2,4-diones(3) were pre-pared by the condensation reaction of 6-alkyl(aryl)-5,6-dihydro-2H-pyran-2,4-diones(1), substituted anilines(2) and ethyl orthoformate. Apair of conformationaLIsomers 4 and 5 exist in products 3 due to the formation of the intramolecular hydrogen bond. Compound 3 was tested in vitro against many fungi such as P. Zeae, C. Arachidicala, P. Piricola, A. Solani, B. Cinerae, S. Sclerotiorum, H. Oryzae, etc . The bioassay results show that they have some fungicidal activity.

Key words: Condensation reaction, Intra molecular hydrogen bond, ConformationaLIsomers, Fungicidal activity

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