高等学校化学学报 ›› 1998, Vol. 19 ›› Issue (8): 1335.

• 论文 • 上一篇    下一篇

磷酸酯-碳酸酯共聚物的合成及其微球释药性能研究

柯天一, 卓仁禧   

  1. 武汉大学化学院, 教育部生物医用高分子材料开放实验室, 武汉, 430072
  • 收稿日期:1997-07-14 出版日期:1998-08-24 发布日期:1998-08-24
  • 通讯作者: 卓仁禧
  • 作者简介:柯天一,男,31岁,博士研究生.
  • 基金资助:

    国家自然科学基金(批准号:59493200)资助课题.

Synthesis of Amphiphilic Phosphate Carbonate-Copolymers and Drug Release Property of Their Microspheres

KE Tian-Yi, ZHUO Ren-Xi   

  1. College of Chemistry, Laboratory of Biomedical Polymer Materials of the Ministry of Education, Wuhan University, Wuhan, 430072
  • Received:1997-07-14 Online:1998-08-24 Published:1998-08-24

摘要: 在光气、二氯磷酸溴乙酯和双酚A反应后,用三甲胺季铵化侧链,得到了4种两亲性磷酸酯-碳酸酯共聚物.用IR、1HNMR及元素分析表征了共聚物,测量了水接触角和Mn,研究了其在pH为7.4磷酸盐缓冲溶液中的降解性能.制得了共聚物微球,并研究了微球的形态、粒径及其对抗肿瘤药物5-Fu的释放性能.

关键词: 两亲性磷酸酯-碳酸酯共聚物, 微球, 体外降解

Abstract: Four amphiphilic phosphate carbonate copolymers were synthesized by polycondensation of bisphenol A, phosgene and 2-bromoethyl phosphorodichloridate, and then quaternized with trimethylamine. The copolymers obtained were characterized by IR, 1HNMR and elemental analysis. Average molecular weight(Mn) and water contact angle were measured. The in vitro degradation of copolymers was studied in pH7.4 phosphate buffer solution at 37 ℃. Microspheres of these coploymer were prepared, their morphology, size and in vitro drug release of 5-Fu were also investigated.

Key words: Amphiphilic phosphate-carbonate copolymer, Microsphere, In vitro degradation

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