高等学校化学学报

高等学校化学学报 ›› 1996, Vol. 17 ›› Issue (7): 1010.

• 论文 • 上一篇    下一篇

钌多吡啶配合物的合成及结合DNA的研究

吴建中, 王雷, 杨光, 曾添贤, 计亮年   

  1. 1. 中山大学化学系, 广州 510275;
    2. 中国科学院兰州化学物理研究所OSSO国家重点实验室
  • 收稿日期:1995-07-17 出版日期:1996-07-24 发布日期:1996-07-24
  • 通讯作者: 计亮年
  • 作者简介:吴建中,男,27岁,博士研究生.
  • 基金资助:

    国家自然科学基金;国家教委博士学科点基金;Tbe Royal Society of Chemistry Research Fund(1995)资助

Synthesis and DNA-binding Studies of Ruthenium Mixed-polypyridyl Complexes

WU Jian-Zhong, WANG Lei, YANG Guang, ZENG Tian-Xian, JI Liang-Nian   

  1. 1. Department of Chemistry, Zhongshan University, Guangzhou 510275;
    2. State Key Laboratory for OSSO, Lanzhou Institute of Chemical Physics, Chineses Academy of Sciences, Lanzhou
  • Received:1995-07-17 Online:1996-07-24 Published:1996-07-24

PDF (PC)

被引次数

69

摘要： 合成了咪唑并[f]邻菲咯啉(IP)和2-苯基咪唑并[f]邻菲咯啉(PIP)两种新的配体及[Ru·(bp)2(IP)]2+(简称b2IP)、[Ru(bpy)2(PIP)]2+(简称b2PIP)、[Ru(phen)2(IP)]2+(简称p2IP)和[Ru(phen)2(PIP)]2+(简称p2PIP)4种新混配物。用电子吸收、稳态发光、圆二色谱研究了配合物与小牛胸腺DNA的结合情况。总的结合强度顺序为:b2IP2PIP≤p2IP2PIP,这与配体的平面大小、π电子扩展程度和疏水性顺序(bpy《phen

关键词: 钌(Ⅱ), 咪唑并[f]邻菲咯啉, 2-苯基咪唑并[f]邻菲咯啉, 小牛胸腺DNA

Abstract: Two new ligands,imidazo[f],10-phenanthroline(IP)and 2-phenylimidazo[f]1,10-phenanthroline(PIP),and four new complexes,[Ru (bpy)2(IP)]2+(b2IP),[Ru (bpy)2(PIP)]2+(b2PIP),[Ru(phen)2(IP)]2+(p2IP)and[Ru(phen)2(PIP)]2+(p2PIP)were synthesized and characterized.The binding of the complexes to calf thymus DNAwas investigated by using electronic absorption,steady-state luminescence and circular dichroism spectra.The order of total binding affinities was found to be b2IP<b2PIP≤p2IP<p2PIP,consistent with the order of the ligands'planarities,π-electron extension and hydrophobicities,bpy《phen

Key words: Ruthenium(Ⅱ), Imidazo[f], 1,10-phenanthroline, 2-phenylimidazo[f]1,10-phenanthroline, Calf thymus DNA

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