高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (8): 1237.

• 论文 • 上一篇    下一篇

冠醚修饰的固体支撑双层类脂膜的形成及性能研究

何玉萼1, 谢明贵1, 赵玉丛1, 田心棣2   

  1. 1. 四川大学化学系, 成都, 610064;
    2. 密执安州立大学生理系
  • 收稿日期:1994-08-27 修回日期:1995-02-15 出版日期:1995-08-24 发布日期:1995-08-24
  • 通讯作者: 何玉萼,女,50岁,副教授.
  • 作者简介:何玉萼,女,50岁,副教授.
  • 基金资助:

    国家自然科学基金

The Formation and Performance of Solid Supported Bilayer Lipid Membranes Modified with Crown Ethers

HE Yu-E1, XIE Ming-Gui1, ZHAO Yu-Cong1, TIEN Xin-Di2   

  1. 1. Department of Chemistry, Sichuan University, Chengdu, 610064;
    2. Department of Physiology, Michigan State University, East Lansing, MI 48824-1101, U.S.A.
  • Received:1994-08-27 Revised:1995-02-15 Online:1995-08-24 Published:1995-08-24

PDF (PC)

被引次数

15

摘要： 用饱和了胆固醇和修饰用冠醚的角鲨烷/氯仿溶液作成膜液,制备了冠醚修饰的固体支撑双层类脂分子膜(s-BLMs).重点考察了成膜物种及技术对膜稳定性及电特征的影响。其膜电势随接触水相中[K+]的变化呈现Nernst响应,线性范围10-4～10-1mol/L.

关键词: 双层类脂膜, 冠醚, 离子传感器

Abstract: Self-assembly solid supported bilayer lipid membranes(S-BLMs)modified with crown ethers were formed on metalic wire.The stability and the electrochemical characteristics of the s-BLMs depended on the variety of metalic wire,organic solvent,lipids and molecular structures of crown ethers. The membrane potentials of the s-BLMs prepared with stainless steel wire in mixed solution of squalane saturated cholesterol and crown ether in CHCl3were determined.The cavity size and negative electricity of the ether ring of crown ethe,r molecules are favorable to the selective complexation with metal cations(M+,e.g. Li+Na+,K+) in the aqueous solution. The change of[M+](10-4-10-1mol/L)would result in a Nernst corresponding in the membrane potential.

Key words: Bilayer lipid membranes, Crown ether, Ion sensor

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