高等学校化学学报

高等学校化学学报 ›› 1995, Vol. 16 ›› Issue (7): 1012.

• 研究快报 • 上一篇    下一篇

辅酶B12模型物/β-环糊精超分子化合物的合成和表征

罗来斌1, 陈慧兰1, 刘君1, 唐雯霞1, KarlS.Hagen2   

  1. 1. 南京大学化学系, 南京大学配位化学国家重点实验室, 南京, 210093;
    2. Emory大学化学系, 亚特兰大, GA, 30332, U.S.A.
  • 收稿日期:1995-01-25 修回日期:1995-04-09 出版日期:1995-07-24 发布日期:1995-07-24
  • 通讯作者: 陈慧兰
  • 作者简介:罗来斌,男,26岁,博士研究生.
  • 基金资助:

    国家自然科学基金

Syntheses and Characterization of Coenzyme B12Analogues/β-CD Supramolecules

LUO Lai-Bin1, CHEN Hui-Lan1, LIU Jun1, TANG Wen-Xia1, KarlS. Hagen2   

  1. 1. Chemistry Department and State Key Laboratory of Coordition Chemistry, Nanjing University, Nanjing, 210093;
    2. Department of Chemistry, Emory University, Atlanta, GA, 30332, U.S.A.
  • Received:1995-01-25 Revised:1995-04-09 Online:1995-07-24 Published:1995-07-24

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摘要： 辅酶B12是多种分子内重排酶和核苷还原酶的辅因子,它的Co-C键在酶催化过程中会断裂产生自由基,引发底物的重排,在催化反应过程中起重要作用,包含Co-C键的辅酶B12模型化合物与环糊精作用形成超分子的研究尚未见报道,由于该超分子比单纯的辅酶β12模型物增加了疏水腔,使模型更接近真实体系,因而研究它们的性质,尤其是Co-C键在包结前后的变化,对于阐明与辅酶B12有关的酶催化反应机理有重要意义,我们以RCo(DMG)2L(R=i-C4H9,n-C4H9,n-C5H11,c-C6H11,PhCH2.DMG=丁二酮肟.L=H2O,NH3)为辅酶B12模型与β-环糊精作用,首次合成了一系列B12模型超分子配合物,并用元素分析、FAB-MS、1HNMR进行了表征.

关键词: 辅酶B12, 烷基钴肟, &beta, -环糊精, 超分子

Abstract: A new kind of supramolecules of coenzyme B12models with β-cyclodextrine, RCo(DMG)2L/β-CD(R=i-C4H9, n-C4H9, n-C5H11, c-C6H11, PhCH2DMG=dimethyl-gly-oxime. L=H2O, NH3), were firstly synthesized and characterized by elementary analysis, FAB-MS and 1HNMR. X-ray structure analysis of i-C4H9Co(DMG)2H2O/β-CD proved that the alkyl group of RCo(DMG)2L was included into the hydrophobic cavity of β-cyclodextrin and the equational DMG was located near the wider opening.

Key words: Coenzyme B12, Cobaloxime, β-cyclodextrin, Supramolecule

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