高等学校化学学报

高等学校化学学报 ›› 1994, Vol. 15 ›› Issue (11): 1620.

• 研究简报 • 上一篇    下一篇

用氧电极结合枯草杆菌M45(Rec-)和H17(Rec+)快速鉴别金属离子的致癌性

李辉1, 迪丽拜尔1, 邓家祺1, 陈中孚2   

  1. 1. 复旦大学化学系, 上海, 200433;
    2. 复旦大学遗传所, 上海, 200433
  • 收稿日期:1993-11-29 修回日期:1994-04-15 出版日期:1994-11-24 发布日期:1994-11-24
  • 通讯作者: 邓家棋.
  • 作者简介:李辉,男,25岁,博士研究生.
  • 基金资助:

    国家教委博士点基金

Rapid Detection of Carcinogenicity of Metal Ions by Using O2 Electrode with Bacillus Subtilis Rec-assay Strains

LI Hui1, Diliber1, DENG Jia-Qi1, CHEN Zhong-Fu2   

  1. 1. Chemistry Department, Genetic Research Institute, Frudan university, Shang Hai, 200433;
    2. Genetic Research Institute, Frudan university, Shang Hai, 200433
  • Received:1993-11-29 Revised:1994-04-15 Online:1994-11-24 Published:1994-11-24

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关键词: 遗传毒性, 金属离子, 枯草杆菌

Abstract: Asimplified, efficient method has been constructed by combining O2 electrode andBacillus subtilis rec-assay strains to detect genetoxicity of various metal ions. The resultsshow that this method can be used to detect genotoxic metal compounds with a high sensitivity and fidelity, and the carcinogenicity of Cr6+, Co2+, Cd2+, Mn2+ ions are confirmed. Themanipulations are very simple, and reproducible responses was gained within half an hour.So this method can be applied to the screening of environmental metal compounds.

Key words: Genetoxicity, Metal ions, Bacillus subtilis

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